{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:49:20Z","timestamp":1791640160291,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Prosthodontics"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the mid\u2010to\u2010long term clinical outcomes of the implant\u2010supported cross\u2010arch fixed dental prostheses (IFCDPs) with monolithic zirconia\u2010based frameworks and related risk factors of success and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This retrospective study encompassed individuals exhibiting terminal dentition or edentulism in the maxilla and\/or mandible who underwent treatment involving IFCDPs with monolithic zirconia frameworks. Inclusion criteria required a documented follow\u2010up period of at least five years post\u2010definitive prosthesis delivery. Evaluation of outcomes focused on the survival rates of implant and prosthesis, along with the incidence of biological and technical complications. The mixed\u2010effects Cox regression model was employed to analyze the risk factors associated with prosthesis failure and peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A cohort of 47 patients, consisting of 14 women and 33 men with a mean age of 55.2 \u00b1 12.5 years (range: 25\u201383), was included in this study. The mean follow\u2010up period was 71.6 \u00b113.2 months (mean \u00b1 SD, range: 60\u2013147). A total of 51 cross\u2010arch prostheses supported by 302 implants, distributed between the maxilla (27 prostheses) and mandible (24 prostheses), were assessed. By the end of the follow\u2010up period, 289 (97.64%) of the 302 implants remained functional. Peri\u2010implantitis was observed in 27 implants (24 in mandible), yielding an overall implant\u2010related success rate of 91.06%. Nine frameworks experienced fractures (eight in mandible), resulting in an overall prosthesis\u2010related survival rate of 82.35%. Subsequent analysis revealed the mandible to be a significant risk factor for framework fracture (HR = 11.64, <jats:italic>p<\/jats:italic> = 0.024) and peri\u2010implantitis (HR = 10.88, <jats:italic>p<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The implant\u2010supported cross\u2010arch fixed dental prostheses featuring monolithic zirconia\u2010based frameworks demonstrated favorable clinical outcomes throughout a 5\u201313\u2010year observation period. Notably, in the design of monolithic zirconia\u2010based framework prostheses, the mandible emerged as a significant risk factor for framework fractures and an independent risk factor for peri\u2010implantitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jopr.13991","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T12:39:17Z","timestamp":1733834357000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A retrospective single cohort study on the 5\u201313 year clinical outcomes of implant\u2010supported cross\u2010arch fixed dental prostheses with monolithic zirconia\u2010based frameworks"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-9822","authenticated-orcid":false,"given":"Jia","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Stomatology Peking University School and Hospital of Stomatology &amp; 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