{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:43:15Z","timestamp":1776422595759,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Prosthodontics"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To characterize the microbiota of implant\u2010supported full\u2010mandible dentures and its correlation to clinical outcomes for up to 5 years after implant loading in patients with a history of periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twelve individuals with a history of periodontitis (Stage IV and Grade B) received five immediate implants and a fixed complete\u2010arch mandibular prosthesis. Microbiological (total counts, microbial profile, and diversity) and clinical outcomes (probing depth, bleeding on probing, and bone resorption) were assessed before tooth extraction and at 4 and 5 years postloading. Thirty\u2010five microbial species were detected and quantified by DNA checkerboard analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The microbiota significantly changed after 5 years of implant loading, with an increase in the abundance of periodontal pathogens and microbial diversity over time. The biofilm microbial profile and genome counts of implants were substantially different from the ones found in the remaining teeth at baseline, but no correlations between microbial taxa\/counts and clinical outcomes were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The microbiota of dental implants was found to be different from the remaining teeth in patients with a history of periodontitis. Significant microbial shifts occurred in the microbiota of implants after 5 years of function; nonetheless, the microbiological changes did not impact clinical outcomes, which were consistent with health throughout the follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jopr.14081","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:34:58Z","timestamp":1749216898000},"page":"478-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbiota and clinical outcomes of implant\u2010supported full\u2010mandible dentures on patients with a history of periodontitis: A 5\u2010year prospective cohort study"],"prefix":"10.1111","volume":"35","author":[{"given":"Jefferson Ant\u00f4nio","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prosthodontics Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi Chokyu","family":"Del\u2010Rey","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Ramos","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivete Aparecida de Mattias","family":"Sartori","sequence":"additional","affiliation":[{"name":"Implantology Area Latin American Institute of Research and Education in Dentistry Curitiba PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssio","family":"do 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