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This study aimed to identify PIU profiles using Latent Profile Analysis, and to analyze the differences in them attending to some of the principal PIU risk and protective factors. A total of 675 Spanish adolescents completed questionnaires assessing PIU, Internet usage, mental health problems, personality, psychological strengths, and family relationships. Four profiles were obtained: Nonproblematic use (68.30% of the sample), Slightly problematic use (17.90% of the sample), Problematic use (8.50% of the sample), and Severe problematic use (5.40% of the sample). Results showed differences between them, with the profile with more PIU having more risk factors and less protective factors. Results showed that many different personal and social variables included in the study play a role in PIU. 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