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Past research suggests that both social support offline and interaction online are linked to adolescent psychological adjustment. However, less is known regarding the complex implications of distinctive sources of social support offline and online interaction for a broader range of indices of adolescent psychosocial well\u2010being, including its contemporary forms such as social media addiction. This study utilized two methodological approaches to examine the social components and determinants of psychosocial well\u2010being (psychosomatic complaints and problematic social media use) among 22,384 Nordic adolescents aged between 11 and 15\u2009years. A variable\u2010centered approach focused on examining perceived support from four sources (family, peers, teachers, and classmates), preference for online interaction, and intensity of online interaction as predictors of psychosocial well\u2010being. Concurrently, a person\u2010centered approach was utilized to explore the subgroups at risk of psychosocial ill\u2010being. In the variable\u2010centered analysis, lower support from family, teachers, and classmates, higher preference for online interaction, and higher intensity of online interaction with \u201conline contacts\u201d (i.e., interaction partners met online) were linked to higher levels of psychosomatic complaints and more problematic social media use. Additionally, lower peer support was associated with increased psychosomatic complaints, while greater intensity of online interaction with \u201coffline contacts\u201d (e.g., close friends, parents) was related to more problematic social media use. The person\u2010centered analysis identified five profiles of adolescents: (1) \u201cMultiply supported online users\u201d (56%), (2) \u201cPrimarily (family\u2010peer) supported high online users\u201d (22%), (3) \u201cNon\u2010supported online users\u201d (13%), (4) \u201cPrimarily non\u2010supported online users\u201d (5%), and (5) \u201cNon\u2010supported high online users\u201d (4%). Adolescents reporting higher support from multiple sources and moderate online interaction with offline contacts experienced the lowest levels of psychosomatic complaints and the least problematic social media use, while the other profiles exhibited more complex and less optimal psychosocial well\u2010being. In conclusion, these findings suggest that adolescents benefit most from robust social support offline across multiple social networks, but strong support from certain sources (teachers, classmates) can somewhat mitigate the adverse effects of low support from other sources (family, peers). 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