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Using the dual\u2010factor model of mental health, this study explored associations between socioecological domains and mental health profiles and subsequent moderations by sex, race and ethnicity, and age. Cross\u2010sectional data were from the Environmental influences on Child Health Outcomes (ECHO) Cohort (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20092826). Adolescents were 11\u201317\u2009years old (mean age 14.4\u2009\u00b1\u20092.1), 55.3% non\u2010Hispanic White, and 48% girls. Using latent profile analysis, four mental health groups were identified: positive mental health; parent\u2010endorsed symptoms, but content; vulnerable; and troubled. Latent regression analyses showed that, overall, better family, peer, and teacher\u2010school relationships were found in the positive mental health group compared with other groups. No significant moderations were observed. Implications for practice and policy are discussed.\n                  <\/jats:p>","DOI":"10.1111\/jora.70029","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:24:46Z","timestamp":1747873486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Socio\u2010ecological domains and adolescent mental health: An application of the dual\u2010factor model"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-088X","authenticated-orcid":false,"given":"Theda","family":"Rose","sequence":"first","affiliation":[{"name":"School of Social Work University of Maryland Baltimore  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences George Washington University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychology Washington State University  Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika S.","family":"Raghunathan","sequence":"additional","affiliation":[{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashelle J.","family":"Musci","sequence":"additional","affiliation":[{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-9578","authenticated-orcid":false,"given":"Alexandra D. 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