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Parental responses to youth's sexual orientation and gender identity (SOGI) are critical in shaping youth mental health outcomes, yet prior research has often simplified these responses into a unidimensional acceptance\u2013rejection continuum. Using data from the 2022 LGBTQ National Teen Survey (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093187 SGM YOC), this study challenged such an oversimplified conceptualization by exploring heterogeneous patterns of parental responses to children's SOGI among SGM YOC. Further, we also examined the distinct implications of each identified profile for SGM YOC's mental health problems and how the association between intersectional microaggressions and mental health problems might vary across the identified profiles. Three distinct SOGI\u2010specific parental response profiles were found:\n                    <jats:italic>High Rejection Low Acceptance Response<\/jats:italic>\n                    (24.10%),\n                    <jats:italic>Low Rejection Low Acceptance Response<\/jats:italic>\n                    (50.30%), and\n                    <jats:italic>Low Rejection High Acceptance Response<\/jats:italic>\n                    (25.60%). Profile membership varied by race\/ethnicity, sex assigned at birth, gender identity, sexual orientation, and caregiver education level. Youth in the\n                    <jats:italic>High Rejection Low Acceptance Response<\/jats:italic>\n                    profile reported significantly higher levels of mental health problems compared with those in the\n                    <jats:italic>Low Rejection Low Acceptance Response<\/jats:italic>\n                    and\n                    <jats:italic>Low Rejection High Acceptance Response<\/jats:italic>\n                    profiles. SOGI\u2010specific parental response profile membership moderated the association between intersectional microaggressions and mental health problems. Intersectional microaggressions were more strongly associated with mental health problems among youth in the\n                    <jats:italic>Low Rejection Low Acceptance Response<\/jats:italic>\n                    profile than among those in the\n                    <jats:italic>High Rejection Low Acceptance Response<\/jats:italic>\n                    profile, with higher overall mental health problems in the latter profile. By identifying diverse patterns of SOGI\u2010specific parental responses and the differential consequences for understanding how SGM YOC's intersectional minority stress relates to mental well\u2010being, our findings underscore the importance of culturally responsive interventions that engage parental figures as active agents of affirmation, support, and socialization, ultimately fostering SGM YOC's positive development amid intersecting systems of oppression.\n                  <\/jats:p>","DOI":"10.1111\/jora.70219","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:50:18Z","timestamp":1782125418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Profiles of parental response, intersectional microaggressions, and mental health problems among sexual and gender minority youth of color"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5773-3622","authenticated-orcid":false,"given":"Shixin","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Human Development and Family Studies The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-8460","authenticated-orcid":false,"given":"Meg D.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Family Science University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5494-7724","authenticated-orcid":false,"given":"Cara L.","family":"Exten","sequence":"additional","affiliation":[{"name":"Edna Bennett Pierce Prevention Research Center The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Ross and Carol Nese College of Nursing The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3635-9499","authenticated-orcid":false,"given":"Hongjian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Psychology The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-3961","authenticated-orcid":false,"given":"Samantha L.","family":"Tornello","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Edna Bennett Pierce Prevention Research Center The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-7714","authenticated-orcid":false,"given":"Ryan J.","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Sciences University of Connecticut  Storrs Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Anti\u2010transgender legislation poses mental health and safety risks for transgender and gender diverse (TGD) youth and their families (child policy briefs)","author":"Abbott S.","year":"2026"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/1550428X.2019.1672232"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jad.12139"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2022.2096047"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0011000019853240"},{"key":"e_1_2_13_7_1","volume-title":"Cultural foundations and interventions in Latino\/a mental health: History, theory and within group differences","author":"Adames H. 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