{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:20:01Z","timestamp":1773832801599,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T00:00:00Z","timestamp":1569628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Renal Care"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis increases the risk of cardiovascular disease in the general population by triggering systemic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the relationship between systemic inflammation and periodontitis, and clarify any association between severe periodontitis and the medications used by patients receiving haemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>The study was undertaken with 56 patients receiving haemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Demographic and laboratory data and prescribed drugs regularly used by patients were recorded from hospital records. During the dialysis session, a validated Xerostomia Inventory score was completed. A complete dental\/periodontal examination was also undertaken on all patients by the same periodontist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the study population, stage I periodontitis was determined in 41%, stage II periodontitis in 17%, stage III periodontitis in 21%, and stage IV periodontitis in 21%. Male gender, hypertension, coronary artery disease, \u03b2 antagonists, calcium channel blockers, sodium polystyrene sulphonate, teeth brushing less than twice a day and high sensitive C\u2010reactive protein\u2009&gt;\u20098\u2009mg\/l were significantly associated with severe periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Drugs, including \u03b2 antagonists, calcium channel blockers, polystyrene sulphonate, co\u2010morbid conditions and poor or insufficient oral care could facilitate an increase in the severity of periodontitis in patients receiving haemodialysis. Severe periodontitis also seems to be associated with cardiovascular disease and inflammation in patients with chronic renal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jorc.12299","type":"journal-article","created":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T04:34:05Z","timestamp":1569731645000},"page":"239-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Could drug burden be associated with severe periodontitis in patients receiving haemodialysis?"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-1048","authenticated-orcid":false,"given":"Hasan H.","family":"Yeter","sequence":"first","affiliation":[{"name":"Department of Nephrology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Erten","sequence":"additional","affiliation":[{"name":"Department of Nephrology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sila C.","family":"Isler","sequence":"additional","affiliation":[{"name":"Department of Periodontology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Soysal","sequence":"additional","affiliation":[{"name":"Department of Periodontology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehri","family":"Elbeg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrin","family":"Unsal","sequence":"additional","affiliation":[{"name":"Department of Periodontology Gazi University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,28]]},"reference":[{"key":"e_1_2_10_1_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05470610"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137636"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.218"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00933.x"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu015"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X10666140214122234"},{"key":"e_1_2_10_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0157"},{"key":"e_1_2_10_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2009.00107.x"},{"key":"e_1_2_10_1_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.01.018"},{"key":"e_1_2_10_1_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.174359"},{"key":"e_1_2_10_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12506"},{"key":"e_1_2_10_1_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V451205"},{"key":"e_1_2_10_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.017"},{"key":"e_1_2_10_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007892"},{"key":"e_1_2_10_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.02.006"},{"key":"e_1_2_10_1_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-26"},{"key":"e_1_2_10_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0716-z"},{"key":"e_1_2_10_1_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2017.05.003"},{"key":"e_1_2_10_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2015.02.015"},{"key":"e_1_2_10_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.523"},{"key":"e_1_2_10_1_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_10_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2007.tb00059.x"},{"key":"e_1_2_10_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02485.x"},{"key":"e_1_2_10_1_26_1","first-page":"1","article-title":"Xerostomia: prevalence and pharmacotherapy. 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