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No systematic review and meta\u2010analyses study about the effect of intervention (invasive and noninvasive intervention) on the arteriovenous fistula cannulation\u2010related pain has yet been carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This systematic review with meta\u2010analysis was conducted to assess the evidence for the effectiveness of intervention to reduce the arteriovenous fistula cannulation\u2010related pain in patients undergoing haemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using English databases, including PubMed, Web of Science, Scopus, Science Direct, ProQuest, ProQuest Dissertations &amp; Theses Global, and EBSCOHOST were systematically searched from their inception to April 2025. Two reviewers independently assessed the risk of bias using the JBI RCT checklist. The Comprehensive Meta\u2010Analysis\u00ae software version 3.0 (Biostat) was used for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two randomised controlled trials examined the effects of interventions to alleviate the arteriovenous fistula cannulation\u2010related pain including invasive and noninvasive interventions related studies. Invasive interventions buttonhole cannulation, using plastic needle and using indwelling needles. Noninvasive methods include cryotherapy or using a local skin cooling device, aromatherapy, foot reflexology, US\u2010guided cannulation, antistress balls, listening to music or running water, virtual reality distraction, breathing exercise, and acupressure on patients with haemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrated that invasive and noninvasive interventions had beneficial effects on the fistula cannulation\u2010related pain. However, due to the heterogeneity and the lack of follow\u2010up studies, more high\u2010quality studies are needed to confirm the results of our review and to clarify the long\u2010term effects of interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jorc.70028","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T08:54:16Z","timestamp":1752828856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Interventions to Reduce Arteriovenous Fistula Cannulation\u2010Related Pain in Patients Undergoing Haemodialysis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-0474","authenticated-orcid":false,"given":"Nurten","family":"Ozen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Nursing, Faculty of Nursing Istanbul University Istanbul Turkey"},{"name":"\u0130stanbul \u00dcniversitesi Hem\u015firelik Fak\u00fcltesi \u0130stanbul Fatih Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-4035","authenticated-orcid":false,"given":"Nese ALTINOK.","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Nursing, Faculty of Nursing Hacettepe University Ankara Turkey"},{"name":"Hacettepe \u00dcniversitesi Hem\u015firelik Fak\u00fcltesi Ankara Samanpazar\u0131 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-8225","authenticated-orcid":false,"given":"Gulsah","family":"Kesik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Nursing, Faculty of Nursing Hacettepe University Ankara Turkey"},{"name":"Hacettepe \u00dcniversitesi Hem\u015firelik Fak\u00fcltesi Ankara Samanpazar\u0131 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics5030053"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.215141"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2009.03.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016040412"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12803"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.13152"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2020-209567"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.15171\/jcs.2017.014"},{"issue":"3","key":"e_1_2_12_10_1","first-page":"117","article-title":"The Effect of Transcutaneous Electrical Nerve Stimulation on the Pain Intensity During Insertion of Vascular Needles in Hemodialysis Patients","volume":"5","author":"Asgari M. 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