{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:55:09Z","timestamp":1792004109320,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Renal Care"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Informal caregivers increasingly support people with chronic kidney disease, yet caregiving is often associated with substantial physical, emotional, and financial burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To synthesise the characteristics and effectiveness of interventions designed to reduce burden among informal caregivers of people with chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Informal caregivers of people with chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>A search was conducted of CINAHL, PubMed, Embase, PsycINFO, and Web of Science databases from inception to February 2025, as well as citation chaining and hand searching. Randomised control trials, quasi\u2010and non\u2010randomised controlled trials, and single\u2010group pre\u2010post studies, conducted at any location and published in English were included. Risk of bias was assessed using Joanna Briggs Institute Checklists. GRADE was used to assess certainty of evidence. Random\u2010effects meta\u2010analyses were conducted for caregiver burden outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen studies were included in the review, investigating education interventions, mindfulness, relaxation, logotherapy, peer mentoring, and behaviour modification. Twelve studies identified a significant reduction in caregiver burden. A meta\u2010analysis of five education and skills training interventions found overall reduction in caregiver burden. Heterogeneity was high, which limited comparability. Certainty of evidence for caregiver burden was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Brief education\u2010focused programs and selected behaviour\u2010change interventions may reduce the burden for informal caregivers of people with chronic kidney disease. However, additional high\u2010quality studies conducted in a variety of contexts incorporating robust methods are required to identify the benefits and optimal characteristics of interventions to inform kidney care teams.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO (CRD420250651266)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jorc.70063","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:48:04Z","timestamp":1779270484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interventions to Reduce Burden Among Informal Caregivers of People With Chronic Kidney Disease: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"Kerri M.","family":"Gillespie","sequence":"first","affiliation":[{"name":"School of Nursing and Midwifery Griffith University Southport QLD Australia"},{"name":"Mater Research Institute University of Queensland South Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Purtell","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Griffith University Southport QLD Australia"},{"name":"Kidney Health Service, Metro North Health Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Finderup","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Schjerning","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9920-6743","authenticated-orcid":false,"given":"Ann","family":"Bonner","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Griffith University Southport QLD Australia"},{"name":"Kidney Health Service, Metro North Health Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2020.03.012"},{"key":"e_1_2_12_3_1","article-title":"Assessment of Burden in Caregivers of Patients Undergoing Hemodialysis and Peritoneal Dialysis: A Cross\u2010Sectional Study in Riyadh, Saudi Arabia","volume":"16","author":"Alaryni A. 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