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We address gaps in the literature by examining: (1) how risk and protective factors co\u2010occur, and (2) how different risk\/protection profiles are associated with violence and bullying perpetration among adolescent boys.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data came from the population\u2010based 2016 Minnesota Student Survey. The analytic sample included boys in grades 8, 9, and 11 (N\u00a0=\u00a063,818). Latent profile analyses identified patterns of 22 behavioral, intrapersonal, family, and school and community risk\/protective factors. Logistic regression analyses examined how these patterns related to violence and bullying perpetration.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We identified 5 groups: Class 1: <jats:styled-content style=\"fixed-case\"><jats:italic>Low risk, high safety, high connectedness<\/jats:italic><\/jats:styled-content>; Class 2: <jats:styled-content style=\"fixed-case\"><jats:italic>Low risk, moderate safety, moderate connectedness<\/jats:italic><\/jats:styled-content>; Class 3: <jats:styled-content style=\"fixed-case\"><jats:italic>Moderate risk, high safety, moderate connectedness<\/jats:italic><\/jats:styled-content>; Class 4: <jats:styled-content style=\"fixed-case\"><jats:italic>High risk, moderate safety, low connectedness<\/jats:italic><\/jats:styled-content>; and Class 5: <jats:styled-content style=\"fixed-case\"><jats:italic>High risk, low safety, low connectedness<\/jats:italic><\/jats:styled-content>. Compared to Class 1, Class 5 students had the highest odds of all for violence and bullying perpetration. Class 4 students also demonstrated high odds of violence and bullying, compared to Class 1. Though not as high as Classes 4 or 5, Class 2 and 3 students showed higher odds for both outcomes, compared to Class 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Substantive variations exist in boys who engage in violence and bullying. We highlight cumulative, co\u2010occurring risk factors, connectedness to parents and other prosocial adults (eg, teachers), and school and neighborhood safety as important factors to address in school health programs seeking to prevent violence and bullying perpetration among boys.<\/jats:p><\/jats:sec>","DOI":"10.1111\/josh.12867","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T05:25:12Z","timestamp":1577942712000},"page":"212-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Profiles of Risk and Protection for Violence and Bullying Perpetration Among Adolescent Boys"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-0897","authenticated-orcid":false,"given":"Lindsay A.","family":"Taliaferro","sequence":"first","affiliation":[{"name":"Assistant Professor, (Lindsay.Taliaferro@ucf.edu), Department of Population Health Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, FL 32827."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Doty","sequence":"additional","affiliation":[{"name":"Assistant Professor, (Jennifer.doty@ufl.edu), Department of Family, Youth, and Community Sciences, University of Florida, McCarty Hall D, Gainesville, FL 32611."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Gower","sequence":"additional","affiliation":[{"name":"Research Associate, (gowe0009@umn.edu), Division of General Pediatrics and Adolescent Health, Department of Pediatrics, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Querna","sequence":"additional","affiliation":[{"name":"Postdoctoral Fellow, (kquerna@umn.edu), Division of General Pediatrics and Adolescent Health, Department of Pediatrics, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Rovito","sequence":"additional","affiliation":[{"name":"Assistant Professor, (Michael.Rovito@ucf.edu), Department of Health Sciences, University of Central Florida, 12805 Pegasus Drive, HPA I, Orlando, FL 32816."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10826-018-1096-2"},{"key":"e_1_2_6_3_1","unstructured":"US Centers for Disease Control and Prevention. 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