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The objective of this study was to examine the association between food insecurity and substance use behaviors among US high school students.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Data from the 2017 Youth Risk Behavior Survey in 10 states were combined to examine the association between household food insecurity and adolescent use of alcohol, marijuana, prescription opioid misuse, and illicit drugs using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among surveyed respondents, 12.3% of high school students reported experiencing food insecurity. In unadjusted analyses, the prevalence of substance use was higher among students with food insecurity compared to food secure students: current binge drinking (16.2% vs 11.5%), current marijuana use (24.0% vs 16.2%), lifetime prescription opioid misuse (21.3% vs 12.6%), and lifetime use of illicit drugs (12.3% vs 5.0%) (all p\u2009&lt;\u2009.05). In adjusted models, food insecurity was associated with lifetime prescription opioid misuse and lifetime use of illicit drugs (aPR 1.38 and 1.70, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Students with food insecurity are a potential group at a higher rise of substance misuse and may benefit from prevention programs designed to address their needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/josh.13118","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T05:54:56Z","timestamp":1638165296000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Food Insecurity and Its Association With Alcohol and Other Substance Use Among High School Students in the United States"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-4494","authenticated-orcid":false,"given":"Victoria E.","family":"Turner","sequence":"first","affiliation":[{"name":"Andrew Young School of Policy Studies Georgia State University  14 Marietta St NW Atlanta GA 30303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewditu","family":"Demissie","sequence":"additional","affiliation":[{"name":"Division of Adolescent and School Health, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  1600 Clifton Rd NE Atlanta GA 30329 USA"},{"name":"U.S. Public Health Service Commissioned Corps  1101 Wootton Parkway, Suite 300 Rockville MD 20852 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Sliwa","sequence":"additional","affiliation":[{"name":"Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention  4770 Buford Hwy NE Atlanta GA 30341 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather B.","family":"Clayton","sequence":"additional","affiliation":[{"name":"Division of Adolescent and School Health, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention Centers for Disease Control and Prevention  1600 Clifton Rd NE Atlanta GA 30329. 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