{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:24:54Z","timestamp":1759335894692},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,2]],"date-time":"2012-12-02T00:00:00Z","timestamp":1354406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Aim<\/jats:title>Sickle\u2010cell disease (SCD<\/jats:styled-content>) is more prevalent in A<\/jats:styled-content>ustralia due to increased migration; however, the A<\/jats:styled-content>ustralian paediatric SCD<\/jats:styled-content> population has not been previously described. This study aimed to identify the demographic features of and quantify the hospital resource utilisation in the SCD<\/jats:styled-content> population at The R<\/jats:styled-content>oyal C<\/jats:styled-content>hildren's H<\/jats:styled-content>ospital in V<\/jats:styled-content>ictoria.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective chart review of SCD<\/jats:styled-content> patients who presented to the R<\/jats:styled-content>oyal C<\/jats:styled-content>hildren's H<\/jats:styled-content>ospital over a 10.5\u2010year period. Descriptive analyses were conducted.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010seven SCD<\/jats:styled-content> patients aged from 0.2 to 18.0 years (mean: 8.5 \u00b1 4.8 years) had 535 admissions over the 10.5\u2010year period. The population was made up of 28 homozygous sickle\u2010cell disease, 1 sickle C<\/jats:styled-content> disease and 8 sickle\u2010cell beta patients from a variety of ethnic backgrounds. Admissions included 264 unplanned admissions, that is 258 admissions via the emergency department and 6 admissions via outpatients, and 271 planned admissions. Mean length of stay for unplanned admissions was 3.2 \u00b1 2.6 days. Common diagnoses for unplanned admissions were 187 vaso\u2010occlusive crisis (70.8%), 32 infections (12.1%) and 26 anaemic episodes (9.8%). Transfusion therapy (91.9%) accounted for the majority of planned admissions.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Children with sickle\u2010cell disease in an A<\/jats:styled-content>ustralian setting require hospitalisation for various reasons related to disease, either unexpected complications or elective procedures. Factors affecting the provision of optimal healthcare to be explored include the multicultural demographics of the SCD<\/jats:styled-content> population, the timely management of vaso\u2010occlusive crises and the availability of SCD<\/jats:styled-content>\u2010related protocols.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12018","type":"journal-article","created":{"date-parts":[[2012,12,3]],"date-time":"2012-12-03T08:49:35Z","timestamp":1354524575000},"page":"68-71","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hospitalisations for sickle\u2010cell disease in an A<\/scp>ustralian paediatric population"],"prefix":"10.1111","volume":"49","author":[{"given":"Yvonne","family":"Teoh","sequence":"first","affiliation":[{"name":"Department of Paediatrics The University of Melbourne Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthea","family":"Greenway","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Savoia","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Monagle","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Roy","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Barnes","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60287-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1182\/blood.V77.2.214.214","article-title":"Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology","volume":"77","author":"Hebbel RP","year":"1990","journal-title":"Blood"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198824000-00019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.28-7-259"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.2.776.bloodjournal862776"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17192-4"},{"key":"e_1_2_7_9_1","first-page":"832","volume-title":"Disorders of Hemoglobin: Genetics, Pathophysiology, Clinical Management","author":"Nagel RL","year":"2001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_7_11_1","unstructured":"Department of Immigration and Citizenship.Population flows: immigration aspects.2009. 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