{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:40:23Z","timestamp":1780072823142,"version":"3.54.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The goal of this study is to describe secondary hyperparathyroidism in extremely low birthweight (<jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content>) neonates and their response to enteral calcium carbonate (<jats:styled-content style=\"fixed-case\"><jats:roman>CaCO<jats:sub>3<\/jats:sub><\/jats:roman><\/jats:styled-content>) supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case series was conducted on extremely low birth infants, &lt;1000\u2009g birthweight, who survived hospitalisation, had no major congenital anomalies and had all their care in our institution<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During this 6\u2010year period, 231 <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants survived hospitalisation at our institution. Of the 231 patients, parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) levels were performed in 66 of these patients (29%) and were elevated in 54 patients (82% of those tested). The timing of this testing was sporadic and was often performed after recognising osteopenia on radiography. Of the 54 patients with high <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels, 44 (81%) were treated with <jats:styled-content style=\"fixed-case\"><jats:roman>CaCO<jats:sub>3<\/jats:sub><\/jats:roman><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels were monitored while on therapy. The average duration of therapy was 41 \u00b1 28 days, with 64% of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels returning to normal before discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> is a major hormone responsible for bone resorption, and serum levels may be a useful marker in identifying <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> neonates at risk for metabolic bone disease. <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> neonates with secondary hyperparathyroidism may benefit from enteral supplementation with <jats:styled-content style=\"fixed-case\"><jats:roman>CaCO<jats:sub>3<\/jats:sub><\/jats:roman><\/jats:styled-content>. Further studies are needed to better evaluate the incidence, timing and potential treatment of hyperparathyroidism in <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12052","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T15:44:48Z","timestamp":1357573488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Parathyroid hormone levels in neonates with suspected osteopenia"],"prefix":"10.1111","volume":"49","author":[{"given":"Alvaro","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology University of Texas Medical Branch (UTMB)  Galveston Texas United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"February","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology University of Texas Medical Branch (UTMB)  Galveston Texas United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Geary","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology University of Texas Medical Branch (UTMB)  Galveston Texas United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-9-47"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f8b295"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.2.F82"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-35-20"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70011-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199102000-00020"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)31214-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114484"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1455"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328345361b"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900115"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-3-533"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2451"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2008.00861.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.12.029"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508102446"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-203-43574"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.6.447"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPLGCZR7IPVHA7"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)33348-X"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01901.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508153130705"},{"key":"e_1_2_9_25_1","first-page":"229","article-title":"Bone mineralization in infants","volume":"8","author":"Koo WW","year":"1984","journal-title":"Prog. 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