{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T19:44:24Z","timestamp":1751917464045,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T00:00:00Z","timestamp":1357171200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Education and Culture"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aims to determine the risk factors associated with mortality and necrotising enterocolitis (<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>) among very low birthweight infants in 95 neonatal intensive care units in the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etwork on <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>aternal and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ewborn <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional study using an international collaborative database of 17\u2009595 very low birthweight infants admitted within 28 days of birth between 2003 and 2006 in four <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian countries. Information on the mortality and morbidity of neonates admitted to the neonatal intensive care units was recorded. Factors associated with the death and diseases of infants were estimated using multilevel multivariate logistic regression. Random effects were included to account for the clustering of the observations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall discharge mortality was 15% and it was significantly different by countries and units. The mortality rate was found to be significantly higher in neonates with pulmonary haemorrhage (odds ratio 1.83, 95% confidence interval 1.63\u20132.04) and air leak syndrome (odds ratio 1.51, 95% confidence interval 1.30\u20131.72). The incidence of <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content> was 4.3% and was strongly associated with other morbidities. Multivariate logistic regression showed that patent ductus arteriosus was the most significant risk factor associated with <jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our analysis has highlighted the great potential that multi\u2010country, collaborative datasets have in terms of epidemiologic research when it comes to identifying issues in perinatal health that are common throughout <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia, and in relation to particular issues pertaining to specific countries and neonatal units. Establishing collaborative networks, conducting analyses of common datasets and further epidemiologic research are now essential measures to improve newborn health in Asia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12054","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T08:30:59Z","timestamp":1357201859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors associated with outcomes of very low birthweight infants in four <scp>A<\/scp>sian countries"],"prefix":"10.1111","volume":"49","author":[{"given":"Windy Mariane Virenia","family":"Wariki","sequence":"first","affiliation":[{"name":"Research Center of Manado State University  Tondano Indonesia"},{"name":"Department of Global Health Policy Graduate School of Medicine The University of Tokyo  Bunkyo\u2010ku"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rintaro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Health Policy National Center for Child Health and Development  Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nem\u2010Yun","family":"Boo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Faculty of Medicine and Health Science Universiti Tunku Abdul Rahman  Kajang"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene Guat Sim","family":"Cheah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Paediatrics Institute Kuala Lumpur Hospital  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Osaka Medical Center and Research Institute for Maternal and Child Health  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neonatology National University Health System"},{"name":"Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kar Yin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Queen Mary Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707601"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01648.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.046268"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-12-17"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2005.00583.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.157800"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2004.046730"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.106569"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.1.F40"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01685.x"},{"key":"e_1_2_9_14_1","first-page":"349","article-title":"The morbidity and survival of very\u2010low\u2010birth\u2010weights infants in Taiwan","volume":"44","author":"Tsou KI","year":"2003","journal-title":"Acta Paediatr. 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