{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:46:45Z","timestamp":1773226005957,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Objectives<\/jats:title>The aims of this study were to evaluate the specificity of a non\u2010draining hepatobiliary scintigraphy (HBS<\/jats:styled-content>) for biliary atresia (BA<\/jats:styled-content>) in preterm and full\u2010term babies, to verify the relationship between non\u2010draining scan and higher levels of direct bilirubin and to find an objective criterion to guide the time in performing HBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 175 infants (113 males and 62 females, median age of 45 days) with 181 HBS<\/jats:styled-content> performed in T<\/jats:styled-content>uen M<\/jats:styled-content>un H<\/jats:styled-content>ospital between J<\/jats:styled-content>anuary 1998 and M<\/jats:styled-content>ay 2010 were retrospectively analysed. A \u2018non\u2010draining\u2019 scan was defined as one showing no excretion of radiolabelled tracer into the small bowel 24\u2009h after injection. The disease category, epidemiological and laboratory data were compared between infants having non\u2010draining and draining scans. In addition, the predictive value of a negative scan for BA<\/jats:styled-content> was compared between preterm and full\u2010term infants.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty infants (11.4%) were surgically confirmed to have BA<\/jats:styled-content>. A non\u2010draining scan was found to be 100% sensitive for BA<\/jats:styled-content>, and the specificity was 96% and 78% among full\u2010term infants and preterm infants, respectively. The mean direct bilirubin values of infants with BA<\/jats:styled-content> and intrahepatic cholestasis were 141.9 and 111.3\u2009\u03bcmol\/L<\/jats:styled-content>, respectively, which were significantly higher than 67.2\u2009\u03bcmol\/L<\/jats:styled-content> seen in infants with draining scans. This analysis shows that using direct bilirubin \u226563\u2009\u03bcmol\/L<\/jats:styled-content> as an objective criterion in guiding the time to perform HBS<\/jats:styled-content> is most cost\u2010effective.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our data supported that using direct bilirubin \u226563\u2009\u03bcmol\/L<\/jats:styled-content> as an objective criterion in guiding the time to perform HBS<\/jats:styled-content> will avoid unnecessary scans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12067","type":"journal-article","created":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T05:44:21Z","timestamp":1356155061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcome of hepatobiliary scanning: preterm versus full\u2010term cholestatic infants"],"prefix":"10.1111","volume":"49","author":[{"given":"Luen Yee","family":"Siu","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Tuen Mun Hospital New Territories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Nin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET Hong Kong Sanatorium and Hospital Happy Valley Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Wah","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Tuen Mun Hospital New Territories"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngai Shan","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Tuen Mun Hospital New Territories"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200408000-00001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60946-6"},{"key":"e_1_2_9_4_1","first-page":"1279","article-title":"Outcome of hepatobiliary scanning in neonatal hepatitis syndrome","volume":"38","author":"Gilmour SM","year":"1997","journal-title":"J. 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