{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:21:21Z","timestamp":1780334481820,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T00:00:00Z","timestamp":1358812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014607","name":"Royal Children's Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014607","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to investigate whether height, weight, head circumference and\/or relationships between these factors are associated with gross motor milestone acquisition in children with achondroplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Population\u2010based data regarding timing of major gross motor milestones up to 5 years were correlated with height, weight and head circumference at birth and 12 months in 48 children with achondroplasia born in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand between 2000 and 2009.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although as a group children with achondroplasia showed delayed gross motor skill acquisition, within group differences in height, weight or head circumference did not appear to influence timing of gross motor skills before 5 years. The exception was lie to sit transitioning, which appears likely to occur earlier if the child is taller and heavier at 12 months, and later if the child has significant head\u2010to\u2010body disproportion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study to investigate the relationship between common musculoskeletal impairments associated with achondroplasia and timing of gross motor achievement. Identification of the musculoskeletal factors that exacerbate delays in transitioning from lying to sitting will assist clinicians to provide more proactive assessment, advice and intervention regarding motor skill acquisition for this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12078","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T08:52:36Z","timestamp":1358844756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effect of height, weight and head circumference on gross motor development in achondroplasia"],"prefix":"10.1111","volume":"49","author":[{"given":"Penelope Jane","family":"Ireland","sequence":"first","affiliation":[{"name":"Queensland Paediatric Rehabilitation Service Royal Children's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S","family":"Ware","sequence":"additional","affiliation":[{"name":"School of Population Health The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Donaghey","sequence":"additional","affiliation":[{"name":"Queensland Paediatric Rehabilitation Service Royal Children's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"McGill","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine Royal Children's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zankl","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verity","family":"Pacey","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ault","sequence":"additional","affiliation":[{"name":"Department of Paediatric Rehabilitation The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Savarirayan","sequence":"additional","affiliation":[{"name":"Victorian Clinical Genetics Service Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sillence","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Thompson","sequence":"additional","affiliation":[{"name":"South Australia Clinical Genetics Service Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharron","family":"Townshend","sequence":"additional","affiliation":[{"name":"Genetics Service of Western Australia King Edward Memorial Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M","family":"Johnston","sequence":"additional","affiliation":[{"name":"Cerebral Palsy League of Queensland \u2013 Fortitude Valley  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32485"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470540"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199706000-00001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320410215"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181c72052"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320090105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2011.04050.x"},{"key":"e_1_2_9_9_1","first-page":"189","article-title":"Orthopedic aspects of achondroplasia in children","volume":"48","author":"Kopits SE","year":"1988","journal-title":"Basic Life Sci."},{"key":"e_1_2_9_10_1","first-page":"8","article-title":"Skeletal growth and development of the achondroplastic dwarf","volume":"116","author":"Nehme AM","year":"1976","journal-title":"Clin. 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