{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:46:13Z","timestamp":1697445973959},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,10]],"date-time":"2013-03-10T00:00:00Z","timestamp":1362873600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe cases of confirmed central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) tuberculosis seen at the major tertiary referral centre of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>ueensland over a 10\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective case series\u2010based study of all cases of proven <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium tuberculosis<\/jats:italic> infection of the CNS presenting to a major tertiary referral centre of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>ueensland between 2000 and 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five cases of confirmed <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> tuberculosis were identified over the 10\u2010year period with two deaths. All were from <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>apua <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uinea with a mean age of 7 years. Imaging and early microbiological diagnosis was critical in making the diagnosis. HIV infection was not a contributing factor. Multidrug resistance was inferred or confirmed in two cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> tuberculosis is a disease being increasingly seen in <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>ueensland among children from <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>apua <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uinea. Anticipation of multidrug resistance is important in the immediate management of suspected cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12107","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T01:04:02Z","timestamp":1363136642000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Central nervous system tuberculosis: A disease from <scp>P<\/scp>apua <scp>N<\/scp>ew <scp>G<\/scp>uinea in <scp>N<\/scp>orth <scp>Q<\/scp>ueensland"],"prefix":"10.1111","volume":"49","author":[{"given":"Pascallina LC","family":"Ting","sequence":"first","affiliation":[{"name":"The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Norton","sequence":"additional","affiliation":[{"name":"The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1596\/978-0-8213-8316-2"},{"key":"e_1_2_8_3_1","unstructured":"Centers for Disease Control and Prevention.Morbidity tables reporting areas.2008. 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