{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:40:27Z","timestamp":1791344427339,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Mechanical in\u2010exsufflation (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>) augments the weakened cough of patients with neuromuscular disease (<jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content>), clearing secretions and overcoming atelectasis. Little has been published on the impact of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> alone on rates of hospitalisation and quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>). The aim of this study was to assess the impact of home <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> on hospital admissions and life\u2010style in children with <jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was performed on children using <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>, including data on the number of admissions to hospital, length of stay and hours of ventilation. A parental survey was used to gather information on the impact of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> on life\u2010style for the child and family.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten children with <jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content> (seven spinal muscular atrophy, two <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>uchenne muscular dystrophy and one centronuclear myopathy) using <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> at home were identified. <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> use commenced at mean age of 8.5 years (range 1.1\u201316.9) with 1.4 years of use (range 0.3\u20133.8). <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> pressures ranged from +\/\u221230 to 40\u2009<jats:styled-content style=\"fixed-case\">cmH<jats:sub>2<\/jats:sub>O<\/jats:styled-content> with no complications reported. There was a significant reduction in hospital days at 6 (<jats:italic>P<\/jats:italic>\u2009=\u20090.036) and 12 (<jats:italic>P<\/jats:italic>\u2009=\u20090.028) months following commencement of home <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> compared with the same period preceding <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> use. The survey highlighted positive benefits of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> use, in particular the ability to treat many pulmonary exacerbations at home.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Home <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> use by children with <jats:styled-content style=\"fixed-case\">NMD<\/jats:styled-content> can reduce hospitalisation and benefit families by maintaining their child at home.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12111","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T12:09:22Z","timestamp":1361880562000},"page":"233-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Effect of home mechanical in\u2010exsufflation on hospitalisation and life\u2010style in neuromuscular disease: A pilot study"],"prefix":"10.1111","volume":"49","author":[{"given":"Fiona CE","family":"Moran","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Spittle","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of Melbourne  Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Delany","sequence":"additional","affiliation":[{"name":"Department of Children's Bioethics Centre Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Department of Physiotherapy University of Melbourne  Melbourne Victoria 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