{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:44:02Z","timestamp":1782906242107,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aims to assess the usefulness of duodenal bulb biopsy in the diagnosis of coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) in a paediatric population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Since <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2009, in our institution, we have routinely included duodenal bulb biopsy in addition to distal duodenal biopsies in children undergoing diagnostic upper gastrointestinal endoscopy. All children diagnosed with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2009 and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2011 were identified, and those children who had biopsy finding of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> limited to duodenal bulb were reviewed with regard to clinical, serological and histopathological parameters. Duodenal bulb biopsy reports of those children who did not have <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> were also reviewed as control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 101 children were diagnosed with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> during the study period. The mean age was 8.21 years (\u00b13.63), 33 males and 68 females. There were 8 out of 101 (7.92%) who had histological changes consistent with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> exclusively in the duodenal bulb, with normal histology in the distal duodenum. None of duodenal bulb biopsy was abnormal in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>n some children, diagnostic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> changes may be limited to the duodenal bulb only and hence we recommend that duodenal bulb biopsies be included routinely in children suspected with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> to improve the diagnostic yield.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12123","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T16:26:30Z","timestamp":1361550390000},"page":"210-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Duodenal bulb biopsy in children for the diagnosis of coeliac disease: Experience from <scp>P<\/scp>erth, <scp>A<\/scp>ustralia"],"prefix":"10.1111","volume":"49","author":[{"given":"Ajay","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Princess Margaret Hospital for Children  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Mews","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Princess Margaret Hospital for Children  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Jevon","sequence":"additional","affiliation":[{"name":"Department of Histopathology Princess Margaret Hospital for Children  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhur","family":"Ravikumara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Princess Margaret Hospital for Children  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00356-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32832f5b9d"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200402000-00019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.557"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.153"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200501000-00001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_7_9_1","unstructured":"British Society Of Paediatric Gastroenterology Hepatology and Nutrition (BSPGHAN).Guideline for the diagnosis and management of coeliac disease in children: Coeliac Working Group of BSPGHAN.2006. 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