{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:39Z","timestamp":1791274419687,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T00:00:00Z","timestamp":1363651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,4]]},"abstract":"\n Aim<\/jats:title>\n Sensitisation to allergens and allergy symptoms depends on age, but this relationship is poorly understood. We therefore investigated the effect of age on allergen sensitisation and allergy symptoms in pre\u2010school children.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cross\u2010sectional study was conducted on 629\n K<\/jats:styled-content>\n orean children (age 3 to 6 years). Current allergic symptoms were assessed by the\n K<\/jats:styled-content>\n orean version of the\n I<\/jats:styled-content>\n nternational\n S<\/jats:styled-content>\n tudy of\n A<\/jats:styled-content>\n sthma and\n A<\/jats:styled-content>\n llergies in\n C<\/jats:styled-content>\n hildhood questionnaire that was adapted for pre\u2010school children. Sensitisation to five airborne and three food allergens was evaluated by a skin prick test. \u03c7\n 2<\/jats:sup>\n test was used to analyse differences in age trend. Multiple logistic regression analysis was performed to obtain the adjusted odds ratios (\n aOR<\/jats:styled-content>\n ) for allergic disease.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A<\/jats:styled-content>\n s age increased, the prevalence of current rhinitis (\n P<\/jats:italic>\n < 0.001), the sensitisation to pollen allergens (\n P<\/jats:italic>\n < 0.001) and polysensitised children (\n P<\/jats:italic>\n = 0.002) increased, but the prevalence of current asthma (\n P<\/jats:italic>\n = 0.010) and the sensitisation to food allergens (\n P<\/jats:italic>\n = 0.009) decreased. There was no effect of age on the prevalence of current eczema (\n P<\/jats:italic>\n = 0.685), monosensitised children (\n P<\/jats:italic>\n = 0.282) and atopy (\n P<\/jats:italic>\n = 0.160). The agreement between sensitisation to dust mites and atopy increased with age, and was 93% at age 6 years (\n P<\/jats:italic>\n = 0.05). The polysensitisation (\n aOR<\/jats:styled-content>\n = 3.0 (95%\n CI<\/jats:styled-content>\n , 1.4\u20135.0),\n P<\/jats:italic>\n < 0.005) and the presence of eczema in the first 2 years of life (\n aOR<\/jats:styled-content>\n = 4.1 (95%\n CI<\/jats:styled-content>\n , 2.2\u20137.6),\n P<\/jats:italic>\n < 0.001) were significant independent risk factors for current rhinoconjunctivitis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The type and number of allergen sensitisations and allergic symptoms changed from age 3 to 6 years. Careful follow\u2010up of changes in sensitisation patterns may provide a better understanding of the pathogenesis of the allergic march.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.12150","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T07:33:18Z","timestamp":1363678398000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Patterns of sensitisation to common food and inhalant allergens and allergic symptoms in pre\u2010school children"],"prefix":"10.1111","volume":"49","author":[{"given":"Hyeong Yun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Bundang JeSaeng General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"CHA University College of Medicine Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Yung","family":"Yum","sequence":"additional","affiliation":[{"name":"Seoul Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Mi","family":"Jee","sequence":"additional","affiliation":[{"name":"CHA University College of Medicine Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Jung","family":"Jang","sequence":"additional","affiliation":[{"name":"CHA University College of Medicine Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Won","family":"Yoon","sequence":"additional","affiliation":[{"name":"CHA University College of Medicine Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Yong","family":"Han","sequence":"additional","affiliation":[{"name":"CHA University College of Medicine Seongnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.10.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03765.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03435.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61388-8"},{"key":"e_1_2_8_9_1","first-page":"81","article-title":"Is high prevalence of vitamin D deficiency evidence for asthma and allergy risks?","volume":"43","author":"Ehlayel MS","year":"2011","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70195-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2008.51.4.343"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2011.08.004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03206.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.00993.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2011.54.1.1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.00042.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03046.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.3055"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.06.042"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03992.x"},{"key":"e_1_2_8_21_1","first-page":"483","article-title":"Sensitization rates for inhalant allergens in Korea; a multi\u2010center study","volume":"23","author":"Kim TB","year":"2003","journal-title":"Korean J. Asthma Allergy Clin. Immunol."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01066.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-994OC"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00570.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118786"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00864.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.648"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922809354326"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00856.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70303-8"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0668.2006.00460.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00804.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e33"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12150","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.12150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:46:24Z","timestamp":1697273184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.12150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,19]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/jpc.12150"],"URL":"https:\/\/doi.org\/10.1111\/jpc.12150","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,19]]},"assertion":[{"value":"2012-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}