{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:46:07Z","timestamp":1771476367115,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the survival of non\u2010syndromic live born infants diagnosed in <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>ueensland with congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Case note audit was completed of all live born newborns with a diagnosis of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> admitted between <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 1987 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2010. Demographic and clinical data were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival to time of discharge for all infants was 67.3% (<jats:italic>n<\/jats:italic> = 35\/52). For infants born before 2003 survival was 59.5% and for those born in 2003 and onwards was 86.7% (<jats:italic>P<\/jats:italic> = 0.10, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.4, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.87\u201322.55). Infants born prior to 2003, compared to those born from 2003 onwards, were less likely to survive with an isolated defect (<jats:italic>P<\/jats:italic> = 0.04, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 8.0, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.93\u201368.62). Isolated congenital diaphragmatic hernia survival since 2003 was 92.3%. A significant difference was found in the time to surgery with those born in 2003 onwards having surgery significantly later, median 134\u2009h, compared to the earlier cohorts median time to surgery of 83\u2009h (<jats:italic>P<\/jats:italic> &lt; 0.005, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 32.61\u2013167.09). Premature infants had poorer survival (46.7%) compared to term infants (75.7%) (<jats:italic>P<\/jats:italic> &lt; 0.0001 <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.99\u20136.68). Univariate analysis identified low birthweight was associated with poorer survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival to discharge in our cohort equals other reported rates in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia and around the world, including centres with tertiary paediatric services. The current management strategies used for these infants have seen a significant improvement in outcomes over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12211","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T10:05:44Z","timestamp":1370253944000},"page":"475-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Congenital diaphragmatic hernia in <scp>N<\/scp>orthern <scp>Q<\/scp>ueensland"],"prefix":"10.1111","volume":"49","author":[{"given":"Liza","family":"Edmonds","sequence":"first","affiliation":[{"name":"Department of Neonatology The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherie","family":"Boniface","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Alcock","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Stalewski","sequence":"additional","affiliation":[{"name":"Department of Surgery The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Surgery The Townsville Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01436.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2425-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2257-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211794"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.03.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.03.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2845"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.01.073"},{"key":"e_1_2_8_11_1","first-page":"1479","article-title":"Perinatal outcome of congenital diaphragmatic hernia in an Australian tertiary hospital","volume":"51","author":"O'Mahony E","year":"2011","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"e_1_2_8_12_1","unstructured":"SPSS Inc.2009)PASW (formally SPSS) Statistics 18. 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