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Juvenile idiopathic arthritis remains a clinical diagnosis of exclusion, but further research may delineate biological markers associated with the disease and its subtypes. Therapy for patients includes intra\u2010articular steroid injections, disease modifying agents such as methotrexate and biological agents. Biological agents have provided exciting new therapeutic options in the last decade; however, long\u2010term side effects of modulating the immune system are not yet fully understood. Systemic steroids may also be required but their long\u2010term use is avoided. Uveitis needs to be screened for in all of those with the diagnosis. Multidisciplinary team care is required in managing these young people.<\/jats:p>","DOI":"10.1111\/jpc.12218","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T11:14:52Z","timestamp":1367838892000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Juvenile idiopathic arthritis in the new world of biologics"],"prefix":"10.1111","volume":"49","author":[{"given":"Genevieve Tyra","family":"Ostring","sequence":"first","affiliation":[{"name":"Department of Paediatrics Waitakere Hospital  Auckland New Zealand"},{"name":"The School of Medicine, Paediatrics The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davinder","family":"Singh\u2010Grewal","sequence":"additional","affiliation":[{"name":"The John Hunter Children's Hospital  Newcastle New South Wales Australia"},{"name":"The Department of Rheumatology The Sydney Children's Hospitals Network, Randwick and Westmead Campuses  Sydney New South Wales Australia"},{"name":"Discipline of Paediatric and Child Health The University of Sydney  Sydney New South Wales Australia"},{"name":"School of Maternal and Child Health The University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Paediatrics The University of Western Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,6]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"1989","article-title":"Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort","volume":"29","author":"Oen K","year":"2002","journal-title":"J. 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