{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:41:06Z","timestamp":1766086866190},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Aim<\/jats:title>We aimed to characterise the demographic and clinical features of paediatric community\u2010associated S<\/jats:styled-content>taphylococcus aureus<\/jats:italic> (CA\u2010SA<\/jats:styled-content>) infection. We aimed to identify factors associated with methicillin\u2010resistant S<\/jats:styled-content>.\u2009aureus<\/jats:italic> (MRSA<\/jats:styled-content>) infection evident at the point of care with the potential to guide antibiotic choice.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective chart review in 2008 of CA\u2010SA<\/jats:styled-content> infections at the Children's Hospital at Westmead (CHW<\/jats:styled-content>), a 300\u2010bed tertiary paediatric hospital in western S<\/jats:styled-content>ydney, A<\/jats:styled-content>ustralia. We calculate rates of MRSA<\/jats:styled-content> and perform univariate and multivariate analysis for predictors of MRSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 431 patients with CA\u2010SA<\/jats:styled-content> infections, 19.3% were MRSA<\/jats:styled-content>. In univariate analysis, MRSA<\/jats:styled-content> was predicted by age greater than 1 year, Aboriginal race, rural\/regional residence, previous history of skin and soft tissue infection (SSTI<\/jats:styled-content>) or a family history of SSTI<\/jats:styled-content>, at least 48\u2009h of antibiotics active against methicillin\u2010sensitive S<\/jats:styled-content>.\u2009aureus<\/jats:italic> (MSSA<\/jats:styled-content>), invasive infection and abscess formation. In a multivariate analysis factors that independently predicted MRSA<\/jats:styled-content> in the entire cohort, and in the non\u2010invasive subgroup included abscess formation, a family history of staphylococcal infection or SSTI<\/jats:styled-content>, Aboriginal ethnicity, at least 48\u2009h of anti\u2010MSSA<\/jats:styled-content> antibiotics at presentation, presentation during spring and age greater than 1 year.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>One fifth of CA\u2010SA<\/jats:styled-content> infections at our tertiary paediatric hospital in 2008 were MRSA<\/jats:styled-content>. Several clinical and demographic factors evident at the point of care were highly significant predictors of CA\u2010MRSA<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12255","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T05:21:38Z","timestamp":1369977698000},"page":"754-759","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Paediatric community\u2010associated S<\/scp>taphylococcus aureus<\/i>: A retrospective cohort study"],"prefix":"10.1111","volume":"49","author":[{"given":"Philip N","family":"Britton","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infectious Diseases The Children's Hospital at Westmead Sydney New South Wales Australia"},{"name":"Discipline of Paediatrics and Child Health The University of Sydney Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N","family":"Andresen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases The Children's Hospital at Westmead Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043252"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31818a3450"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00081-09"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/528716"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2008.07.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000207404.50143.1e"},{"key":"e_1_2_7_8_1","first-page":"84","article-title":"Genotypes, intrafamilial transmission, and virulence potential of nasal methicillin\u2010resistant Staphylococcus aureus from children in the community. 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