{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:18:57Z","timestamp":1769843937725,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Aim:\u2003<\/jats:title>To compare the pregnancy outcomes in terms of perinatal morbidities and mortality for different types of assisted reproductive technology (ART<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods:\u2003<\/jats:title>A retrospective cohort study was conducted of all babies born by ART<\/jats:styled-content> in S<\/jats:styled-content>ingapore General Hospital, between 1 N<\/jats:styled-content>ovember 2001 and 11 J<\/jats:styled-content>anuary 2012.<\/jats:p><\/jats:sec>Results:\u2003<\/jats:title>Incidence of ART<\/jats:styled-content> was 3.5% in our birth cohort. Pregnancies conceived by ART<\/jats:styled-content> were more likely to be multiple pregnancies OR<\/jats:styled-content> 43.50, and were more likely to be premature OR<\/jats:styled-content> 5.51. Mortality OR<\/jats:styled-content> was 3.93. IVF<\/jats:styled-content>\/ICSI<\/jats:styled-content> contributed to an increased OR<\/jats:styled-content> for multiple gestation of 48.26, an increased OR<\/jats:styled-content> for prematurity of 5.95 and increased OR<\/jats:styled-content> for low birthweight of 5.54. Mortality OR<\/jats:styled-content> was 4.33. Intrauterine insemination (IUI<\/jats:styled-content>)\/clomiphene may represent a lower risk group compared with in vitro fertilisation\/intracytoplasmic sperm injection (IVF<\/jats:styled-content>\/ICSI<\/jats:styled-content>). Prematurity OR<\/jats:styled-content> was only 2.35, and low birthweight OR<\/jats:styled-content> was 2.38. These were less than half of IVF<\/jats:styled-content>\/ICSI<\/jats:styled-content>. Fewer neonatal morbidities were found. Mortality was insignificant. Multiplicity had significant impact on perinatal outcomes in ART<\/jats:styled-content> and IVF<\/jats:styled-content>\/ICSI<\/jats:styled-content> but not in IUI<\/jats:styled-content>\/clomiphene conceptions, demonstrated by singleton subgroup analyses and by logistic regression using prematurity as outcome.<\/jats:p><\/jats:sec>Conclusion:\u2003<\/jats:title>IUI<\/jats:styled-content>\/clomiphene represented an intermediate risk group compared with the IVF<\/jats:styled-content>\/ICSI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12257","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T03:12:55Z","timestamp":1371093175000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Perinatal outcomes of intrauterine insemination\/clomiphene pregnancies represent an intermediate risk group compared with in vitro fertilisation\/intracytoplasmic sperm injection and naturally conceived pregnancies"],"prefix":"10.1111","volume":"49","author":[{"given":"Woei Bing","family":"Poon","sequence":"first","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital Singapore Singapore"},{"name":"Duke\u2010NUS Medical School Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee Bin","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital Singapore Singapore"},{"name":"Duke\u2010NUS Medical School Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4274\/tpa.46.07"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32112-0"},{"key":"e_1_2_9_4_1","volume-title":"Births: Final Data for 2002","author":"Martin JA","year":"2003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.5"},{"key":"e_1_2_9_6_1","first-page":"62","article-title":"Perinatal outcomes of newborn infants conceived by assisted reproductive techniques in Royan Institute","volume":"3","author":"Mozafari Kermani R","year":"2009","journal-title":"International Journal of Fertility and Sterility."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02069-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.8.2110"},{"key":"e_1_2_9_9_1","unstructured":"Joint production by the National Population and Talent Division of the Prime Minister's Office Singapore Department of Statistics Ministry of Home Affairs Immigration & Checkpoints Authority. 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