{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:58:23Z","timestamp":1765807103988},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,9]],"date-time":"2013-06-09T00:00:00Z","timestamp":1370736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Leslie Stevens Fund for Newborn Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the short\u2010term outcomes of Australian buprenorphine\u2010exposed mother\/infant dyads.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective record review of drug\u2010exposed mothers and infants in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia. Groups were based on drug exposure: buprenorphine (55, 3.8%), non\u2010buprenorphine opiates (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>, 686, 48.6%) and non\u2010opiates (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, 671, 47.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More than 30% of buprenorphine mothers continued to use heroin (21, 38%) and benzodiazepines (16, 29%). They were more likely to have child at risk concerns (29, 52.7%, <jats:italic>P<\/jats:italic> = 0.019) and have previous children placed in out\u2010of\u2010home care (9, 16.3%, <jats:italic>P<\/jats:italic> = 049). Buprenorphine babies were less likely to be preterm (16% vs. 25% (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>), <jats:italic>P<\/jats:italic> = 0.001 and 23% (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), <jats:italic>P<\/jats:italic> = 0.004) and had higher birthweights (median: 3165\u2009g vs. 2842.5\u2009g (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>), <jats:italic>P<\/jats:italic> &lt; 0.001 and 2900\u2009g (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>), <jats:italic>P<\/jats:italic> = 0.004). Buprenorphine and non\u2010buprenorphine opioid babies had similar maximum Finnegan scores (median 10 vs. 11(<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>), <jats:italic>P<\/jats:italic> = 0.144). The number of babies needing abstinence treatment (45% vs. 51% (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>), <jats:italic>P<\/jats:italic> = 0.411) and length of hospital stay (median days 9 vs. 11(<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>), <jats:italic>P<\/jats:italic> = 0.067) were similar, but buprenorphine infants required lower maximum morphine doses (mg\/kg\/day) (median 0.4\u2009mg vs. 0.5\u2009mg (<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>), <jats:italic>P<\/jats:italic> = 0.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010term medical outcomes of infants of buprenorphine\u2010using mothers are similar to those of non\u2010buprenorphine opiate\u2010using mothers, but interpretation of these results is confounded by the high rates of polydrug exposure in the buprenorphine group. This and other social concerns noted in buprenorphine mothers and infants warrant further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12264","type":"journal-article","created":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T04:37:43Z","timestamp":1370839063000},"page":"746-753","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Perinatal outcomes of <scp>A<\/scp>ustralian buprenorphine\u2010exposed mothers and their newborn infants"],"prefix":"10.1111","volume":"49","author":[{"given":"Pankaj","family":"Patel","sequence":"first","affiliation":[{"name":"The Department of Newborn Care Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E","family":"Abdel\u2010Latif","sequence":"additional","affiliation":[{"name":"Department of Neonatology Centenary Hospital for Women and Children  Canberra Australian Capital Territory Australia"},{"name":"School of Clinical Medicine Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briony","family":"Hazelton","sequence":"additional","affiliation":[{"name":"The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Wodak","sequence":"additional","affiliation":[{"name":"Alcohol and Drug Service St. Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Chen","sequence":"additional","affiliation":[{"name":"The Department of Newborn Care Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Emsley","sequence":"additional","affiliation":[{"name":"The Department of Newborn Care Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Feller","sequence":"additional","affiliation":[{"name":"Sydney Children's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Lui","sequence":"additional","affiliation":[{"name":"The Department of Newborn Care Royal Hospital for Women  Sydney New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Lee","family":"Oei","sequence":"additional","affiliation":[{"name":"The Department of Newborn Care Royal Hospital for Women  Sydney New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01031.x"},{"key":"e_1_2_8_3_1","unstructured":"Australian Institute of Health and Welfare.Statistics on drug use in Australia 2006. 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