{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:27:41Z","timestamp":1789266461048,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Nutritional vitamin B<jats:sub>12<\/jats:sub> deficiency among children in developing countries may lead to a severe clinical status. In this article, the clinical manifestations of vitamin B<jats:sub>12<\/jats:sub> deficiency and the consequences of delay in its diagnosis have been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 41 patients who were hospitalised and treated with the diagnosis of severe vitamin B<jats:sub>12<\/jats:sub> deficiency in the paediatric haematology department of the hospital were enrolled in the trial. The diagnosis of severe vitamin B<jats:sub>12<\/jats:sub> deficiency was based on haematological values, a serum vitamin B<jats:sub>12<\/jats:sub> level of &lt;100\u2009pg\/mL and a normal level of folic acid. Mental, neuro\u2010motor and social developments of the enrolled patients were assessed by the same physician using the Ankara Developmental Screening Inventory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of 25 male and 16 female patients was determined as 12 (6\u201318 months) months. Almost all of the children had been fed with breast milk and a poor nutritional state was found in all of the mothers. Non\u2010specific findings such as growth retardation (78%), hyperpigmentation of the skin (78%), diarrhoea (63.4%), convulsion (14.6%), weakness, reluctance to eat, vomiting, irritability and tremor were found in all the patients, in addition to hypotonia, motor retardation and pallor. Treatment with vitamin B<jats:sub>12<\/jats:sub> provided recovery in all the patients. The mean age of the patients with full recovery was 11.7 months, while the mean age of patients with partial recovery was 12.9 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a delay in the diagnosis causes irreversible neurological damage, early diagnosis and treatment is highly important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12292","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T11:52:18Z","timestamp":1371642738000},"page":"820-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Clinical and neurological findings of severe vitamin <scp>B<sub>12<\/sub><\/scp> deficiency in infancy and importance of early diagnosis and treatment"],"prefix":"10.1111","volume":"49","author":[{"given":"Nihat","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Pediatrics YYU School of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Koc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology Marmara University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokman","family":"\u00dcstyol","sequence":"additional","affiliation":[{"name":"Department of Pediatrics YYU School of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Peker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatology YYU School of Medicine  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Abuhandan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Harran University  \u015eanl\u0131urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0559-4_6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1402-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.8.921"},{"key":"e_1_2_5_5_1","first-page":"730","article-title":"Observations on nutritional megaloblastic anemia in early childhood","volume":"57","author":"Mittal VS","year":"1969","journal-title":"Indian J. Med. Res."},{"key":"e_1_2_5_6_1","first-page":"19","article-title":"Cobalamin and folate deficiency: acquired and hereditary disorders in children","volume":"36","author":"Rosenblatt DS","year":"1999","journal-title":"Semin. Hematol."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-006-0598-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2575-6_14"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-3-199402010-00006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132440"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.684"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.2.255"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81897-9"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/258173a0"},{"key":"e_1_2_5_15_1","volume-title":"Ankara Developmental Screening Inventory Manual","author":"Savasir I","year":"1998"},{"key":"e_1_2_5_16_1","first-page":"467","volume-title":"Nathan and Oski's Hematology of Infancy and Childhood","author":"Watkins D","year":"2009"},{"key":"e_1_2_5_17_1","first-page":"17","article-title":"Neurologic findings of nutritional vitamin B12 deficiency in children","volume":"52","author":"Incecik F","year":"2010","journal-title":"Turk. J. Pediatr."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000212958.89091.c0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981249"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.24001.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01463.x"},{"key":"e_1_2_5_22_1","first-page":"1091","article-title":"Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey","volume":"4","author":"Ta\u015fkesen M","year":"2011","journal-title":"Turk. J. Med. Sci."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00774.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120108"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12217"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532806X107430"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01059.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.2.137"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.1997.00205.x"},{"key":"e_1_2_5_30_1","first-page":"62","article-title":"Bebeklerin n\u00f6ro\u2010motor, sosyal ve fiziksel geli\u015fmeleri \u00fczerine B12 vitamini eksikli\u011finin etkileri","volume":"54","author":"Erta\u015f T","year":"2011","journal-title":"\u00c7ocuk Sa\u011fl\u0131\u011f\u0131 ve Hastal\u0131klar\u0131 Dergisi"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.2.137"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.12292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:33:33Z","timestamp":1696167213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.12292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,18]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/jpc.12292"],"URL":"https:\/\/doi.org\/10.1111\/jpc.12292","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,18]]},"assertion":[{"value":"2013-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}