{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:52:38Z","timestamp":1784173958510,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>A systematic review was conducted to examine the effects of restrictive versus liberal red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) transfusion thresholds on clinically important outcomes in very low birth weight (<jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content>) infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomised controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) of varying <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion thresholds in <jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content> infants were identified by searching <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>, all of the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ibrary and other supplementary sources. Selected studies included one of the following outcomes: total number of red blood cell transfusions, donor exposure rate, cranial ultrasonographically diagnosed brain injury, retinopathy of prematurity, bronchopulmonary dysplasia, necrotising enterocolitis or death. Studies to be included were selected by two reviewers who also assessed the risk of bias of each trial. Data extraction and analyses were independently performed by two reviewers. All data were analysed using <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ev<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>an 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s were identified. One trial did not meet the inclusion criteria, while two had inadequate methodological quality. Pooled analysis of two trials showed that the restrictive transfusion group received a significantly lower mean number of transfusions per infant (mean difference (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) \u22121.35, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) [\u22122.61, \u22120.09]) and donor exposure rate (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> \u22120.54, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22120.93, \u22120.15]). No other statistically significant differences were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Restrictive <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion thresholds in <jats:styled-content style=\"fixed-case\">VLBW<\/jats:styled-content> infants may be utilised without incurring clinically important increases in the risk of death or major short\u2010term neonatal morbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12409","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:56:58Z","timestamp":1381543018000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Masitah","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina Kah Ying","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheo Lian","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30273-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496419"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.e19"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.9-11-e520"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/pch\/7.8.553","article-title":"Position statement. Red blood cell transfusions in newborn infants: revised guidelines","volume":"7","author":"Fetus and Newborn Committee of the Canadian Paediatric Society","year":"2002","journal-title":"Paediatr. Child Health"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.019760"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2008.06.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.2.194"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70097-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70048-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00934.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02373.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.7-2-e69"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.8.959"},{"key":"e_1_2_9_16_1","first-page":"671","article-title":"Current risk for transfusion transmitted infections","volume":"14","author":"Dodd RY","year":"2007","journal-title":"Curr. Opin. Hematol."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.11.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02073381"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.3.514"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050641"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(01)00115-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050551"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.3.F188"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.04.046"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114754"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-951300"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02542.x"},{"key":"e_1_2_9_28_1","unstructured":"Cochrane Neonatal Review Group ed.Model Teaching Review.2009. Available from:http:\/\/neonatal.cochrane.org\/en\/index.html[accessed 23 July 2012]."},{"key":"e_1_2_9_29_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.05.011"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1884"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(09)60045-0"},{"key":"e_1_2_9_33_1","unstructured":"Review Manager (RevMan) [Computer program]. Version 5.0. Copenhagen: The Nordic Cochrane Centre The Cochrane Collaboration 2008."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199804001-01007"},{"key":"e_1_2_9_36_1","first-page":"165","article-title":"Are regular \u2018top\u2010up\u2019 transfusions necessary in otherwise well, growing premature infants?","volume":"75","author":"Ransome OJ","year":"1989","journal-title":"S. Afr. Med. J."},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030908011"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000512.pub2"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0338"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2010.544647"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2010.269"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3233\/NPM-2009-0067","article-title":"Elective red cell transfusions for anemia of prematurity and development of necrotizing enterocolitis in previously well preterm neonates: incidence and difficulties in proving a cause\u2013effect relation","volume":"2","author":"Holder GL","year":"2009","journal-title":"J. Neonatal Perinat. Med."},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.026"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.015"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3178"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.12409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:49:46Z","timestamp":1696178986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.12409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/jpc.12409"],"URL":"https:\/\/doi.org\/10.1111\/jpc.12409","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,9]]},"assertion":[{"value":"2013-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}