{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:27:26Z","timestamp":1791937646225,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,6]],"date-time":"2013-10-06T00:00:00Z","timestamp":1381017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Aim<\/jats:title>To identify factors that distinguish duct\u2010dependent congenital heart disease (DDCHD<\/jats:styled-content>) from non\u2010DDCHD<\/jats:styled-content> in newborn infants.<\/jats:p><\/jats:sec>Method<\/jats:title>A retrospective, cohort study. The N<\/jats:styled-content>ewborn E<\/jats:styled-content>mergency T<\/jats:styled-content>ransport S<\/jats:styled-content>ervice, V<\/jats:styled-content>ictoria (NETS<\/jats:styled-content>) is a retrieval service for all inter\u2010hospital neonatal transfers, and the R<\/jats:styled-content>oyal C<\/jats:styled-content>hildren's H<\/jats:styled-content>ospital, M<\/jats:styled-content>elbourne (RCH<\/jats:styled-content>) is a paediatric cardiac referral centre for the state of V<\/jats:styled-content>ictoria, A<\/jats:styled-content>ustralia. All infants \u226410 days and \u226534 weeks gestation with suspected CHD<\/jats:styled-content> and\/or persistent pulmonary hypertension of the newborn (PPHN<\/jats:styled-content>), transferred by NETS<\/jats:styled-content> from non\u2010tertiary neonatal units to RCH<\/jats:styled-content>, over a 4\u2010year period.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 142 eligible infants, 81 had DDCHD<\/jats:styled-content> and 61 had non\u2010DDCHD<\/jats:styled-content>, of whom 51 had PPHN<\/jats:styled-content>. Diagnostic accuracy of DDCHD<\/jats:styled-content> by the NETS<\/jats:styled-content> team was 77%. Presence of a heart murmur, abnormal pulses, upper and lower limb blood pressure (BP<\/jats:styled-content>) difference >10\u2009mmHg<\/jats:styled-content>, cardiomegaly, initial SpO<\/jats:roman>2<\/jats:sub><\/jats:styled-content> of <92%, PaO<\/jats:roman><\/jats:styled-content>2<\/jats:sub> <50\u2009mmHg, and pre\u2010post ductal SpO<\/jats:roman>2<\/jats:sub><\/jats:styled-content> difference >10% were significantly associated with DDHCD<\/jats:styled-content> on univariate analysis. No single clinical finding was significantly associated with DDCHD<\/jats:styled-content> on multivariate analysis. Labile SpO<\/jats:roman>2<\/jats:sub><\/jats:styled-content>, abnormal lung parenchyma, mean BP<\/jats:styled-content> <40\u2009mmHg, pH<\/jats:styled-content> <7.25, lactate >5 and FiO<\/jats:roman>2<\/jats:sub><\/jats:styled-content> >0.5 were significantly associated with non\u2010DDCHD<\/jats:styled-content>, but at multivariate analysis only labile SpO<\/jats:roman>2<\/jats:sub><\/jats:styled-content> and mean BP<\/jats:styled-content> <40\u2009mmHg were associated with non\u2010DDCHD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Clinical diagnosis of DDCHD<\/jats:styled-content> outside of a cardiac centre is challenging. No single factor predicts DDCHD<\/jats:styled-content>. Combined interpretation of clinical, physiological and x\u2010ray findings may assist.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12410","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T03:31:40Z","timestamp":1389151900000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Improving diagnostic accuracy in the transport of infants with suspected duct\u2010dependent congenital heart disease"],"prefix":"10.1111","volume":"50","author":[{"given":"Neelam","family":"Gupta","sequence":"first","affiliation":[{"name":"Newborn Emergency Transport Services Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Neonatal Unit John Radcliffe Hospital Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Omar","family":"Kamlin","sequence":"additional","affiliation":[{"name":"Newborn Emergency Transport Services Royal Children's 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