{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:47:51Z","timestamp":1792514871088,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T00:00:00Z","timestamp":1387756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Aim<\/jats:title>Cholangitis is a well\u2010known complication that contributes to morbidity, mortality, as well as health\u2010care utilisation in children with biliary atresia who have undergone the K<\/jats:styled-content>asai portoenterostomy. The aim of the study was to determine the common causative organisms for cholangitis and characterise its burden, health\u2010care resource and service utilisation and cost.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective chart review of children who underwent K<\/jats:styled-content>asai portoenterostomy in our institution from 1988 to 2011. The causative organisms were identified based on culture reports. The burden of the disease was estimated based on the number of patients experiencing one or more episodes of cholangitis. Health\u2010care resource and service utilisation were based on different categories, and cost was computed based on the charges at the institution.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010seven (64.3%) out of 42 children included in the analysis experienced at least one episode of cholangitis. There were a total of 97 episodes of cholangitis, with an average of 3.6 (1\u201315) episodes per patient. The average length of stay per episode of cholangitis was 14.8 (2\u201364) days. Common organisms isolated during blood cultures were K<\/jats:italic><\/jats:styled-content>lebsiella pneumoniae<\/jats:italic>, E<\/jats:italic><\/jats:styled-content>nterococcus<\/jats:italic>, E<\/jats:italic><\/jats:styled-content>scherichia coli<\/jats:italic> and P<\/jats:italic><\/jats:styled-content>seudomonas aeruginosa<\/jats:italic>. The estimated cost per in\u2010patient admission of 15 days (rounded off) for a single episode of cholangitis was $SG<\/jats:styled-content>\u20098986.61 ($US<\/jats:styled-content>\u20097369.02).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The knowledge about the incidence and cost of cholangitis will allow physicians to counsel parents of children newly diagnosed with biliary atresia and to better prepare them both emotionally and financially for what to expect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12463","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T11:51:10Z","timestamp":1387799470000},"page":"196-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cholangitis in children with biliary atresia: Health\u2010care resource utilisation"],"prefix":"10.1111","volume":"50","author":[{"given":"Jie Ying","family":"Lee","sequence":"first","affiliation":[{"name":"Yong Loo Lin, School of Medicine , National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon Tak Keet","family":"Lim","sequence":"additional","affiliation":[{"name":"Yong Loo Lin, School of Medicine , National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng Hock","family":"Quak","sequence":"additional","affiliation":[{"name":"Department of Paediatrics National University Health System Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnan","family":"Prabhakaran","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery National University Health System Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Aw","sequence":"additional","affiliation":[{"name":"Department of Paediatrics National University Health System Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.5.360"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90052-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03492-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.376"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(86)90028-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80195-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.195"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.9.697"},{"key":"e_1_2_9_10_1","first-page":"92","article-title":"Jaundice clearance and cholangitis in the first year following portoenterostomy for biliary atresia","volume":"57","author":"Selvalingam S","year":"2002","journal-title":"Med. 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