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The main outcomes were distribution of locations, response rate, rebound growth rate, spherical and cylinder power before and after treatment, amblyopia rate and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one studies including 425 patients met the inclusion criteria. A total of 70.6% of patients were female, 89.6% of the periorbital IHs were located in the upper or lower eyelid area. The most common administration routes involved oral propranolol and intralesional injection of corticosteroids. The mean response rate was 94.0% for propranolol and 82.3% for corticosteroid (<jats:italic>P<\/jats:italic> = 0.001). The rebound growth rate was 13.9% for propranolol and 12.0% for steroids (<jats:italic>P<\/jats:italic> = 0.71). Astigmatism was reduced in both propranolol and steroid studies (<jats:italic>P<\/jats:italic> &lt; 0.0001, <jats:italic>P<\/jats:italic> &lt; 0.0001), but a significant reduction in spherical power was only demonstrated in propranolol studies (<jats:italic>P<\/jats:italic> = 0.005). A total of 31.1% of patients treated with corticosteroids developed post\u2010operative amblyopia compared with 16.7% of patients treated with propranolol (<jats:italic>P<\/jats:italic> = 0.04). Oral propranolol seemed to induce more temporary adverse events than intralesional corticosteroids administration (24.0% vs. 9.6%, <jats:italic>P<\/jats:italic> = 0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Propranolol may represent an effective therapy for periorbital IHs compared with the use of corticosteroids; however, further randomised control studies are needed to compare adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12464","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T11:58:11Z","timestamp":1387799891000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of periorbital infantile haemangiomas: A systematic literature review on propranolol or steroids"],"prefix":"10.1111","volume":"50","author":[{"given":"Shiqiong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renbing","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengfang","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00626.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.12.003"},{"key":"e_1_2_9_4_1","first-page":"137","article-title":"Preliminary results of propranolol treatment for patients with infantile hemangioma","volume":"53","author":"Corapcioglu F","year":"2011","journal-title":"Turk. 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