{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:41:49Z","timestamp":1792442509830,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Aim<\/jats:title>To investigate whether there was any association between growing pains (GP<\/jats:styled-content>) and periodic limb movements of sleep (PLMS<\/jats:styled-content>) in children referred for polysomnography (PSG<\/jats:styled-content>), in light of the possible shared genetic determinants between GP<\/jats:styled-content> and restless legs syndrome.<\/jats:p><\/jats:sec>Methods<\/jats:title>Records of all 903 children who underwent PSG<\/jats:styled-content> at a paediatric hospital between J<\/jats:styled-content>anuary 2009 and M<\/jats:styled-content>ay 2010 were retrospectively reviewed. Children aged 3\u201316 years, without neuromuscular or neurological\/developmental disorders who were seen by a single sleep physician were included in the analysis. Data extracted included: current GP<\/jats:styled-content>, PLMS<\/jats:styled-content> index, mixed obstructive apnoea\/hypopnoea index and patient demographics. GP<\/jats:styled-content> was diagnosed in the pre\u2010PSG<\/jats:styled-content> consultation.<\/jats:p><\/jats:sec>Results<\/jats:title>GP<\/jats:styled-content> was recorded in 43 of the eligible 230 children referred for PSG<\/jats:styled-content> of whom 25.6% had a PLMS<\/jats:styled-content> index \u22655\/h, significantly higher than in the children without GP<\/jats:styled-content> (10.2%) (odds ratio 3.04, \u03c72<\/jats:sup>\u2009=\u20096.0, P<\/jats:italic>\u2009=\u20090.014). The adjusted odds ratio for the association between GP<\/jats:styled-content> and PLMS<\/jats:styled-content> remained significant at 2.53 (95% CI<\/jats:styled-content> 1.1\u20136.1, P<\/jats:italic>\u2009<\u20090.05). A PLMS<\/jats:styled-content> index \u22655\/h was recorded in 30 of the 230 participants. GP<\/jats:styled-content> and PLMS<\/jats:styled-content> were also significantly multivariately associated with restlessness as the indication for PSG<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Children with GP<\/jats:styled-content> were three times more likely to have a PLMS<\/jats:styled-content> index \u22655\/h than children without GP<\/jats:styled-content> on PSG<\/jats:styled-content>. These results suggest that GP<\/jats:styled-content> may be associated with PLMS<\/jats:styled-content>, giving greater support for the hypothesis that GP<\/jats:styled-content> might lie on the phenotypic spectrum of restless legs syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12493","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T08:57:13Z","timestamp":1392800233000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Growing pains and periodic limb movements of sleep in children"],"prefix":"10.1111","volume":"50","author":[{"given":"Man Wai","family":"Wong","sequence":"first","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Medicine Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Champion","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Anaesthesia and Pain Medicine Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Teng","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Sydney New South Wales Australia"},{"name":"Department of Sleep Medicine Sydney Children's Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.04.045"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36147-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-5-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.26.126.134"},{"key":"e_1_2_9_6_1","first-page":"85","article-title":"\u2018Growing pains\u2019","volume":"57","author":"Brenning R","year":"1960","journal-title":"Sven. 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