{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:32:41Z","timestamp":1791167561971,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NH&MRC","award":["510258"],"award-info":[{"award-number":["510258"]}]},{"DOI":"10.13039\/501100001773","name":"UNSW","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Aims<\/jats:title>\n \n Human cytomegalovirus (\n CMV<\/jats:styled-content>\n ) is the leading infectious cause of congenital infection in developed countries. Globally,\n CMV<\/jats:styled-content>\n seropositivity has been associated with low socio\u2010economic status (\n SES<\/jats:styled-content>\n ); however,\n A<\/jats:styled-content>\n ustralian data are lacking. Therefore, we examined the association between\n SES<\/jats:styled-content>\n and\n CMV<\/jats:styled-content>\n seroprevalence in children and pregnant women.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Three groups were examined: 1, a prospective cohort of\n A<\/jats:styled-content>\n ustralian children aged 0\u201315 years (\n n<\/jats:italic>\n = 220); 2, a clinic\u2010based sample of pregnant women (\n n<\/jats:italic>\n = 778); and 3, a case series of infants and children (\n n<\/jats:italic>\n = 219) with symptomatic congenital\n CMV<\/jats:styled-content>\n infection.\n SES<\/jats:styled-content>\n was determined using a postcode\u2010based score from the Australian Bureau of Statistics.Group 1 was recruited from endocrinology clinics and follow\u2010up at\n P<\/jats:styled-content>\n rince of\n W<\/jats:styled-content>\n ales\n H<\/jats:styled-content>\n ospital and\n C<\/jats:styled-content>\n hildren's\n H<\/jats:styled-content>\n ospital at\n W<\/jats:styled-content>\n estmead. Group 2 was recruited at the\n R<\/jats:styled-content>\n oyal\n H<\/jats:styled-content>\n ospital for\n W<\/jats:styled-content>\n omen. Congenitally infected infants were identified through the\n A<\/jats:styled-content>\n ustralian Paediatric Surveillance Unit.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n CMV<\/jats:styled-content>\n seroprevalence among all children was 20% (95% confidence interval (\n CI<\/jats:styled-content>\n ) 15\u201325%), and there was no association with\n SES<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.58). Seroprevalence among pregnant women was 57% (53\u201360%), and higher rates of\n CMV<\/jats:styled-content>\n seropositivity were associated with lower\n SES<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.001). More congenital\n CMV<\/jats:styled-content>\n cases were reported in the highest socio\u2010economic groups (55%) than the lowest (9%) (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n A marked socio\u2010economic gradient in\n CMV<\/jats:styled-content>\n seroprevalence is evident in Australian pregnant women and cases of congenital\n CMV<\/jats:styled-content>\n but not in unselected\n A<\/jats:styled-content>\n ustralian children. These findings highlight the importance of a community\u2010wide approach to\n CMV<\/jats:styled-content>\n awareness and the potential for hygienic measures to reduce the burden of congenital\n CMV<\/jats:styled-content>\n in\n A<\/jats:styled-content>\n ustralia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.12502","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T04:47:02Z","timestamp":1393994822000},"page":"368-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Congenital cytomegalovirus infection is associated with high maternal socio\u2010economic status and corresponding low maternal cytomegalovirus seropositivity"],"prefix":"10.1111","volume":"50","author":[{"given":"James","family":"Basha","sequence":"first","affiliation":[{"name":"Virology Department of Microbiology SEALS Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"School of Medical Sciences Faculty of Medicine University of New South Wales Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna M","family":"Iwasenko","sequence":"additional","affiliation":[{"name":"Virology Department of Microbiology SEALS Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"School of Medical Sciences Faculty of Medicine University of New South Wales Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Robertson","sequence":"additional","affiliation":[{"name":"Serology Department of Microbiology SEALS Prince of Wales Hospital Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E","family":"Craig","sequence":"additional","affiliation":[{"name":"School of Women's and Children's Health University of New South Wales Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"Virology Department of Microbiology SEALS Prince of Wales Hospital Randwick New South Wales Australia"},{"name":"School of Medical Sciences Faculty of Medicine University of New South Wales Kensington New South Wales Australia"},{"name":"ACPS SOMS and BABS University of New South Wales Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2011.tb03144.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq085"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4713-4718.2005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808000551"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00203-06"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2009.01495.x"},{"key":"e_1_2_9_9_1","unstructured":"SrikanthanS ZurynskiY ElliottEAustralian paediatric surveillance unit: Celebrating 15 years of surveillance. 2008."},{"key":"e_1_2_9_10_1","unstructured":"Australian Bureau of Statistics.2033.0.55.001 \u2013 socio\u2010economic indexes for areas (SEIFA) data cube only 2006. 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