{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:03:29Z","timestamp":1778843009382,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonatal abstinence syndrome (<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>) is an increasingly common disorder diagnosed in infants exposed to various drugs, causing immense financial and social burden. Recommendations from various bodies are for babies to be monitored for 4 to 7 days following birth so that prompt treatment can commence should symptoms develop. We aimed to determine the best post\u2010natal observation period in babies at risk of <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was undertaken of infants \u226535 weeks' gestation who received treatment for <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> in the period 2001\u20132010. During this time, the standard post\u2010natal observation period was a minimum of 7 days. Data including drug exposure, day of admission and day of treatment were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and ten babies were included. Drug exposure was predominantly to opiates (99%); however, most infants (58%) were exposed to additional substances (benzodiazepines, cannabis or amphetamines). Ninety\u2010five per cent of infants were admitted by day 5 of life. Of the babies treated by day 7, 98.5% had been admitted to the nursery by day 5. Infants with polydrug exposure were admitted significantly earlier; however, time to treatment was not significantly different to those exposed to opiate replacement therapy alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our hospital, babies treated for <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> often required admission before day 5. This has implications for hospital resource allocation, suggesting that routine post\u2010natal observation for <jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content> could be shortened to 5 days. Further research is needed to help identify neonates who require more careful post\u2010natal observation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12513","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T03:08:49Z","timestamp":1394766529000},"page":"352-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["How long should infants at risk of drug withdrawal be monitored after birth?"],"prefix":"10.1111","volume":"50","author":[{"given":"Cameron L","family":"Smirk","sequence":"first","affiliation":[{"name":"Newborn Services  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Bowman","sequence":"additional","affiliation":[{"name":"Newborn Services  Parkville Victoria Australia"},{"name":"Women's Alcohol and Drug Service Royal Women's Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lex W","family":"Doyle","sequence":"additional","affiliation":[{"name":"Newborn Services  Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille Omar Farouk","family":"Kamlin","sequence":"additional","affiliation":[{"name":"Newborn Services  Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3212"},{"key":"e_1_2_7_3_1","first-page":"19","article-title":"Assessment and treatment of abstinence in the infant of the drug\u2010dependent mother","volume":"12","author":"Finnegan LP","year":"1975","journal-title":"Int. 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