{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:20Z","timestamp":1792818920419,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Aims<\/jats:title>The aim of the study was to determine the topographic prevalence of lymphoid follicles, lymphoid aggregates, gastric glandular atrophy and intestinal metaplasia among children with chronic abdominal pain. The association between these lesions and age, type of gastritis and H<\/jats:italic><\/jats:styled-content>elicobacter pylori<\/jats:italic> density was also assessed.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 358 patients (mean age: 10, 18 \u00b1 3, 26 years; male\u2009:\u2009female ratio: 0.92) with chronic abdominal pain who had upper gastrointestinal endoscopy were included in the study. The endoscopic and histopathological findings were documented. The prevalence of lymphoid follicles, lymphoid aggregates, atrophy and intestinal metaplasia according to the type of gastritis and their relation with H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic> density were determined.<\/jats:p><\/jats:sec>Results<\/jats:title>H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic> was detected in 214 (59.8%) patients. H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic>\u2010 positive patients were found to be significantly older than H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic>\u2010negative patients (P<\/jats:italic><\/jats:styled-content> < 0.01). The endoscopy revealed that the most common finding observed was antral nodularity in H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic>\u2010positive patients and normal mucosal appearance in H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic>\u2010negative patients. Panmucosal gastritis both in the corpus and antrum and the prevalence of lymphoid follicles and lymphoid aggregates were more frequent in the H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic>\u2010positive group (P<\/jats:italic><\/jats:styled-content> < 0.01). None of the patients had atrophy, whereas 11 patients had intestinal metaplasia. Although positive correlation was obtained between lymphoid lesions and H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic> density, no significant relation was established between intestinal metaplasia, lymphoid lesions and H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic> density.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Lymphoid follicles and lymphoid aggregates in gastric mucosa involving both antrum and corpus significantly correlated with H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic> infection, H<\/jats:italic><\/jats:styled-content>. pylori<\/jats:italic> density and type of gastritis in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12609","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T07:47:53Z","timestamp":1402645673000},"page":"605-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The association between H<\/i><\/scp>elicobacter pylori<\/i> gastritis and lymphoid aggregates, lymphoid follicles and intestinal metaplasia in gastric mucosa of children"],"prefix":"10.1111","volume":"50","author":[{"given":"Nursu","family":"Kara","sequence":"first","affiliation":[{"name":"Department of Pediatrics Sisli Etfal Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafiye","family":"Urganci","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Sisli Etfal Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Kalyoncu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sisli Etfal Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pathology Sisli Etfal Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00165.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(00)00099-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08025-X"},{"key":"e_1_2_7_5_1","first-page":"114","article-title":"Helicobacter pylori infection in Turkish preschool and school children: role of socioeconomic factors and breast feeding","volume":"45","author":"Ertem D","year":"2003","journal-title":"Turk. J. Pediatr."},{"key":"e_1_2_7_6_1","first-page":"221","volume-title":"Pediatric Gastrointestinal Disease","author":"Gold BD","year":"1999"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.0160s1003.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00735.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200011000-00007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00248.x"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"Schistosomes, liver flukes and Helicobacter pylori. IARC working group on the evaluation of carsinogenic risks to humans. Lyon, June 7\u201317, 1994","volume":"61","year":"1994","journal-title":"IARC Monogr Eval Carsinog Risks Hum"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05553.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950220113"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-001-0598-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600585131"},{"key":"e_1_2_7_19_1","first-page":"740","article-title":"The significance of lymphoid follicles in the interpretation of biopsy specimens","volume":"118","author":"Genta RM","year":"1992","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100240050022"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.032"},{"key":"e_1_2_7_22_1","first-page":"135","article-title":"Helicobacter pylori and gastric lymphonodular hyperplasia in children","volume":"87","author":"Rosh JR","year":"1992","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1788-z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.004"},{"key":"e_1_2_7_25_1","first-page":"121","article-title":"Recurrent abdominal pain in children: the utility of upper endoscopy and histopathology","volume":"45","author":"Ukarapol N","year":"2004","journal-title":"Singapore Med. J."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00230.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318298020a"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200405000-00018"},{"key":"e_1_2_7_29_1","first-page":"25","article-title":"Helicobacter pylori infection in pediatric practice","volume":"90","author":"Campbell DI","year":"2005","journal-title":"Arc Dis Child Educ Pract Ed"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1083-4389.2001.00047.x"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.12609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:31:29Z","timestamp":1696498289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.12609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,13]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jpc.12609"],"URL":"https:\/\/doi.org\/10.1111\/jpc.12609","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,13]]},"assertion":[{"value":"2014-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}