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The accelerator hypothesis proposes that overweight and insulin resistance are central to both type 1 and type 2 diabetes and may explain, in part, the rise in type 1 diabetes incidence. The temporal rise in body mass index at type 1 diabetes onset and the observation that pre\u2010diabetic children are heavier and more insulin resistant than their peers suggests convergence of type 1 and type 2 diabetes phenotypes. The influence of insulin resistance may begin <jats:italic>in utero<\/jats:italic>, although the aetiological role of birthweight in type 1 diabetes remains unclear. Further research to elucidate the role of these modifiable risk factors in today's obesogenic environment may provide future potential for diabetes prevention.<\/jats:p>","DOI":"10.1111\/jpc.12616","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T02:41:15Z","timestamp":1401849675000},"page":"874-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Environmental determinants of type 1 diabetes: A role for overweight and insulin resistance"],"prefix":"10.1111","volume":"50","author":[{"given":"Sadia T","family":"Islam","sequence":"first","affiliation":[{"name":"Institute of Endocrinology and Diabetes The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubha","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Diabetes The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E","family":"Craig","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Diabetes The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Discipline of Paediatrics and Child Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60765-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00568.x"},{"key":"e_1_2_9_4_1","volume-title":"IDF Diabetes Atlas","author":"IDF","year":"2013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1648-5"},{"key":"e_1_2_9_6_1","first-page":"115","article-title":"The interplay of autoimmunity and insulin resistance in type 1 diabetes","volume":"13","author":"Nokoff NJ","year":"2012","journal-title":"Discov. 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