{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:26:03Z","timestamp":1791393963536,"version":"4.3.3"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Performance Based Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> deficiency is associated with infectious diseases; however, it is not known whether vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> levels are affected by acute infection. Our aim was to establish whether 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>) levels taken during an acute bacterial infection are representative of baseline levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty children between 6 months and 15 years of age with proven bacterial infections presenting to a tertiary paediatric referral centre had 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> levels taken during their acute infection and again 1 month later provided that they had recovered from their infection, had no subsequent infections and had not been taking vitamin supplements. 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> levels were measured by liquid chromatography mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> at enrolment was 67.5\u2009nmol\/L (standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 22.0), and mean 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> at 1 month follow up was 72.7\u2009nmol\/L (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 25.8) (paired <jats:italic>t<\/jats:italic>\u2010test <jats:italic>P<\/jats:italic> = 0.25). C\u2010reactive protein levels were recorded in 29\/30 patients at enrolment (mean 85.1\u2009mg\/L, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 83.5) and 25\/30 patients at follow\u2010up (mean 4.0\u2009mg\/L, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 3.3) (paired <jats:italic>t<\/jats:italic>\u2010test <jats:italic>P<\/jats:italic> = 0.002). The ethnicity of the participants was <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean or <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ther, 26; <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>amoan, 2; <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>aori, 1; and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese, 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children, 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> levels are not affected by acute bacterial infections; 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> levels taken during acute bacterial infection are representative of baseline levels. 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> levels collected during acute bacterial infection provide reliable information for case\u2010control studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12620","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T07:47:57Z","timestamp":1402645677000},"page":"643-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Are vitamin <scp>D<\/scp> levels affected by acute bacterial infections in children?"],"prefix":"10.1111","volume":"50","author":[{"given":"Alex","family":"Binfield","sequence":"first","affiliation":[{"name":"Department of Paediatrics Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Aird","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Murdoch","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Otago  Christchurch New Zealand"},{"name":"Microbiology Unit Canterbury Health Laboratories  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Elder","sequence":"additional","affiliation":[{"name":"Steroid and Immunobiochemistry Unit Canterbury Health Laboratories  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Walls","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819dba91"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30365-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/07435800.2011.554937"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.06.022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.7.532"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1087S"},{"key":"e_1_2_9_8_1","unstructured":"National Institute of Water and Atmospheric Research.Mean Monthly Sunshine. 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