{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:54:43Z","timestamp":1763535283974},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NHMRC PhD Scholarships for Indigenous Australian Health Research"},{"name":"Australian Academy of Science Douglas and Lola Douglas Scholarships in Medical Science","award":["1017225","436039"],"award-info":[{"award-number":["1017225","436039"]}]},{"name":"NHMRC Practitioner Fellowship","award":["545216"],"award-info":[{"award-number":["545216"]}]},{"name":"NHMRC Career Development Fellowship","award":["1024175"],"award-info":[{"award-number":["1024175"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Acute lower respiratory infections (<jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content>s) are the most common reason for hospitalisation of young children in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>erritory of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia. International studies have linked vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> deficiency with increased risk of <jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content> in paediatric populations, but this has not been explored in tropical regions such as the Top End of the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>erritory. The aim of this study is to determine the prevalence of vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> insufficiency among children hospitalised with <jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>erritory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> serum metabolite (25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>3) levels were retrospectively measured using liquid chromatography\u2013mass spectrometry in 74 children (64% male; 57% <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndigenous) aged less than 3 years admitted to <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>oyal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>arwin <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>erritory of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia between <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2008 and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 44 (59%) <jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content>\u2010classified hospitalisations and 30 (41%) non\u2010<jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content>\u2010classified hospitalisations. The most common <jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content> diagnoses were bronchiolitis (<jats:italic>n<\/jats:italic> = 22, 30%) and pneumonia (<jats:italic>n<\/jats:italic> = 21, 28%), whereas the most common non\u2010<jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content> diagnosis was gastroenteritis (<jats:italic>n<\/jats:italic> = 20, 27%). Overall, 24\/74 (32%) children had 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>3 levels &lt;75\u2009nmol\/L (insufficiency). For children hospitalised with <jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content>, 23% (10\/44) had vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> insufficiency compared with 47% (14\/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11\u20131.03; <jats:italic>P<\/jats:italic> = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> insufficiency was observed in almost one\u2010third of these hospitalised children. Children hospitalised with an <jats:styled-content style=\"fixed-case\">ALRI<\/jats:styled-content> were less likely to have vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12623","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T14:04:16Z","timestamp":1403100256000},"page":"512-518","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vitamin <scp>D<\/scp> insufficiency among hospitalised children in the <scp>N<\/scp>orthern <scp>T<\/scp>erritory"],"prefix":"10.1111","volume":"50","author":[{"given":"Michael J","family":"Binks","sequence":"first","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi C","family":"Smith\u2010Vaughan","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naor","family":"Bar\u2010Zeev","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B","family":"Chang","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"},{"name":"Queensland Children's Respiratory Centre Queensland Medical Research Institute Royal Children's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross M","family":"Andrews","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"From Infancy to Young Adulthood: Health Status in the Northern Territory, 2006","author":"Li SQ","year":"2006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03643.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2002.tb04733.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01594.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601845"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0442"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3029"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61650-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.06.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11592"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b5664"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3054"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065835"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1226-3"},{"key":"e_1_2_9_16_1","volume-title":"The International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Australian Modification (ICD\u201010\u2010AM)","author":"National Centre for Classification in Health","year":"2009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.052936"},{"key":"e_1_2_9_18_1","unstructured":"LeroyJL.ZSCORE06: Stata module to calculate anthropometric z\u2010scores using the 2006 WHO child growth standards.2011."},{"key":"e_1_2_9_19_1","unstructured":"WHO.Child Growth Standards. 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