{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:28:03Z","timestamp":1696472883123},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Aim<\/jats:title>Iron deficiency anaemia (IDA<\/jats:styled-content>), which is reported very commonly among patients with breath holding spells (BHS<\/jats:styled-content>), is the most common presentation of coeliac disease (CD<\/jats:styled-content>). In that aspect, IDA<\/jats:styled-content> may be a common pathway linking these two diseases. The aim of this study was to evaluate the frequency of CD<\/jats:styled-content> in patients with BHS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We studied 348 children with BHS<\/jats:styled-content>, and 470 age\u2010 and sex\u2010matched controls with no known disease. Serological screening for CD<\/jats:styled-content> was performed in all patients by searching for serum tissue transglutaminase immunoglobulin A<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The first group consisted of 348 children with BHS<\/jats:styled-content> (231 males, 117 females; mean age 2.23 \u00b1 1.84\u2009years), and the second group consisted of 470 healthy children (284 males, 186 females; mean age 2.11 \u00b1 1.98\u2009years). A total of 300 (86.2%) patients had cyanotic type of BHS<\/jats:styled-content> only, 27 (7.8%) had pallid type of BHS<\/jats:styled-content> only and 21 (6%) had mixed type of BHS<\/jats:styled-content>. The prevalence of IDA<\/jats:styled-content> was statistically significantly higher in BHS<\/jats:styled-content> patients compared with controls. Tissue transglutaminase immunoglobulin A<\/jats:styled-content> was not detected as positive in any patients in either group; therefore, endoscopic and histopathological examinations were not performed.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our report is the first to describe the frequency of tissue transglutaminase immunoglobulin A<\/jats:styled-content> positivity in patients with BHS<\/jats:styled-content>. There was no evidence of a relationship between CD<\/jats:styled-content> and BHS<\/jats:styled-content>, but IDA<\/jats:styled-content> seems to be an important risk factor in the development of BHS. Therefore, serological screening for CD<\/jats:styled-content> in patients with BHS<\/jats:styled-content> does not seem to be necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12639","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T07:48:16Z","timestamp":1402645696000},"page":"916-919","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Frequency of coeliac disease in children with breath\u2010holding spells"],"prefix":"10.1111","volume":"50","author":[{"given":"Sedat","family":"I\u015fikay","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology Gaziantep Children's Hospital Gaziantep Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eamil","family":"H\u0131zl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Gaziantep University Gaziantep Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.286"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021687"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.183"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.01.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063307.84039.C7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31806907e8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90540-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.06.042"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1672"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03647.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.01.008"},{"key":"e_1_2_8_13_1","first-page":"125","article-title":"Breath holding spells in childhood","volume":"146","author":"DiMario FJ","year":"1992","journal-title":"Am. 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