{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:30:29Z","timestamp":1790983829112,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2014,9]]},"abstract":"\n Aim<\/jats:title>\n \n Despite being one of common preventable deficiency disorders, vitamin B12 (vit\u2010\n B<\/jats:styled-content>\n 12) deficiency can lead to serious health problems both in children and adult. The familiar treatment through parenteral route for vit\u2010\n B<\/jats:styled-content>\n 12 deficiency frequently leads to poor adherence, and adequate response to treatment has lead to interest in oral supplementation. This study investigates the efficacy of oral vit\u2010\n B<\/jats:styled-content>\n 12 treatment in children with nutritional vit\u2010\n B<\/jats:styled-content>\n 12 deficiency.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty\u2010seven children (from 1 month to 17 years) with vit\u2010\n B<\/jats:styled-content>\n 12 levels below 200\u2009pg\/mL were allocated either of two study groups: Group 1 (1\u201320 months) and Group 2 (6\u201317 years) which were subdivided according to the duration of treatment (Group 1A&2A: 4 months; Group 1B&2B: 8 months of 1000\u2009\u03bcg oral vit\u2010\n B<\/jats:styled-content>\n 12, every day for a week, every other day for 2 weeks, 2 days a week for 2 weeks, then once a week).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Vit\u2010\n B<\/jats:styled-content>\n 12 levels among all groups were significantly restored following high oral vit\u2010\n B<\/jats:styled-content>\n 12 doses (\n P<\/jats:italic>\n = 0.013,\n P<\/jats:italic>\n = 0.001), the regimen being more effective in Group1A and Group1B. Correlation analysis of serum vit\u2010\n B<\/jats:styled-content>\n 12 levels and age at the end of treatment revealed a decreasing trend with the increasing patient age (corelation respectively \u221265.2%,\n P<\/jats:italic>\n = 0.08; \u221235.4%;\n P<\/jats:italic>\n = 0.25).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Data from this study indicate that oral vit\u2010\n B<\/jats:styled-content>\n 12 (1000\u2009\u03bcg) for 4 months is effective, giving clinicians more choice, for treatment of children with nutritional vit\u2010\n B<\/jats:styled-content>\n 12 deficiency. However, despite this high dose, lower levels were achieved in older children indicating the necessity of dosage adjustment in accordance with body weight.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.12652","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T09:59:21Z","timestamp":1403085561000},"page":"721-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Oral vitamin\n B<\/scp>\n 12 treatment is effective for children with nutritional vitamin\n B<\/scp>\n 12 deficiency"],"prefix":"10.1111","volume":"50","author":[{"given":"Aysenur","family":"Bahadir","sequence":"first","affiliation":[{"name":"School of Medicine Department of Pediatric Hematology Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar G\u00f6k\u00e7e","family":"Reis","sequence":"additional","affiliation":[{"name":"School of Medicine Department of Pediatric Hematology Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Erduran","sequence":"additional","affiliation":[{"name":"School of Medicine Department of Pediatric Hematology Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/PHN2005921"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-10-329"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.032268"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.05.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132440"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1144-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S129"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-394"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1191"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1173"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1515\/CCLM.2011.084","article-title":"Homocysteine: a biomarker in neurodegenerative diseases","volume":"49","author":"Hermann W","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.05.049"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004655.pub2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/ajcn\/47.1.89","article-title":"Increased urinary methylmalonic acid excretion in breast\u2010fed infants of vegetarian mothers and identification of an acceptable dietary source of vitamin B\u201012","volume":"47","author":"Specker BL","year":"1988","journal-title":"Am. J. Clin. Nutr."}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12652","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.12652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:50:59Z","timestamp":1696229459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.12652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,18]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/jpc.12652"],"URL":"https:\/\/doi.org\/10.1111\/jpc.12652","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,18]]},"assertion":[{"value":"2014-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}