{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:26:43Z","timestamp":1775510803300,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Aim<\/jats:title>High flow nasal cannula therapy (HFNC<\/jats:styled-content>) is an emerging method of non\u2010invasive respiratory support therapy for premature infants. Recent evidence around its safety and efficacy for post\u2010extubation respiratory support is encouraging. However, its effect on long\u2010term respiratory outcomes is not known. The aim of this study is to determine the effect of HFNC<\/jats:styled-content> on respiratory outcomes (chronic lung disease (CLD<\/jats:styled-content>), need for home oxygen) when used to wean babies from continuous positive airway pressure (CPAP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>This retrospective study compared respiratory outcomes in infants born <32 weeks gestation needing any respiratory support at birth in two epochs \u2013 epoch I<\/jats:styled-content> (2004\u20132007) verus epoch II<\/jats:styled-content> (2008\u20132011). HFNC<\/jats:styled-content> was available to be used as a CPAP<\/jats:styled-content> weaning modality in epoch II<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 1286 infants (epoch I<\/jats:styled-content>: 597 vs. epoch II<\/jats:styled-content>: 689), mean (standard deviation) gestation, 28.1 (2.2) versus 28.5 (2.3) weeks were enrolled, with 222 (32%) receiving HFNC<\/jats:styled-content> in epoch II<\/jats:styled-content>. Overall median duration of respiratory support increased by 150\u2009h in epoch II<\/jats:styled-content> (P<\/jats:italic> = 0.03), primarily as HFNC<\/jats:styled-content> hours. A reduction in duration of invasive ventilation and CPAP<\/jats:styled-content> along with 6% (P<\/jats:italic> = 0.01) reduction in CLD<\/jats:styled-content> rates was observed in epoch II<\/jats:styled-content>. No change in home oxygen therapy rates was noted. In logistic regression, HFNC<\/jats:styled-content> had no significant effect on rates of CLD<\/jats:styled-content> or home oxygen.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Introduction of HFNC<\/jats:styled-content> for weaning nasal CPAP<\/jats:styled-content> seems to have a minimal effect on CLD<\/jats:styled-content> rates. The effect of HFNC<\/jats:styled-content> on long\u2010term outcomes needs to be further evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12693","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T09:35:53Z","timestamp":1404984953000},"page":"199-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["High flow nasal cannula for continuous positive airway pressure weaning in preterm neonates: A single\u2010centre experience"],"prefix":"10.1111","volume":"51","author":[{"given":"Arun","family":"Sasi","sequence":"first","affiliation":[{"name":"Monash Newborn Monash Children's Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Monash Newborn Monash Children's Melbourne Victoria Australia"},{"name":"Department of Paediatrics Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006405.pub2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341754"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02070.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03274.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12090"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2742"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.11.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300071"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.1081"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.12.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211828"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211879"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1542\/peds.91.1.135","article-title":"Inadvertent administration of positive end distending pressure during nasal cannula flow","volume":"91","author":"Locke RG","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211647"},{"key":"e_1_2_9_16_1","unstructured":"ChowSSW2013.Report of the Australian and New Zealand Neonatal Network 2011. 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