{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T20:57:56Z","timestamp":1762808276733},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NHMRC Centre of Clinical Research Excellence","award":["546519"],"award-info":[{"award-number":["546519"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe the rate of early\u2010 and late\u2010onset sepsis in neonates admitted to the neonatal intensive care unit at the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>oyal <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>omen's <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital and to compare the rate of late\u2010onset sepsis (<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>) with a published (2008) cohort from the same unit. The secondary aim was to examine clinicians' compliance with antibiotic guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants born &lt;32 weeks' gestation or &lt;1500\u2009g admitted between 1 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2011 and 31 <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2011 were included. Strict definitions of sepsis and compliance with antibiotic guidelines were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and seventy\u2010two infants met the inclusion criteria, with 152 having blood culture evaluations for early\u2010onset sepsis (<jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content>) and 58 having 109 evaluations for <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>. Definite <jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content> occurred in 1.3% with <jats:styled-content style=\"fixed-case\"><jats:italic>E<\/jats:italic><\/jats:styled-content><jats:italic>scherichia coli<\/jats:italic> isolated. The rate of definite <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content> in 2011 of 22% was not significantly different than the 27% in 2008, with coagulase\u2010negative staphylococcus the main isolate. Antibiotic continuation beyond 72\u2009h in infants with negative blood cultures was the main reason for non\u2010compliance with antibiotic guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rate of <jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content> is comparable with published reports and the rate of <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content> has remained stable over a 3\u2010year period. Discontinuation of antibiotics with negative septic markers and blood cultures at 48\u201372\u2009h is encouraged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12715","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T13:54:26Z","timestamp":1408110866000},"page":"294-299","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Stable rates of neonatal sepsis in a tertiary neonatal unit"],"prefix":"10.1111","volume":"51","author":[{"given":"Wei Ling","family":"Lean","sequence":"first","affiliation":[{"name":"Neonatal Services Royal Women's Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille O","family":"Kamlin","sequence":"additional","affiliation":[{"name":"Neonatal Services Royal Women's Hospital  Melbourne Victoria Australia"},{"name":"Murdoch Childrens Research Institute  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology (Royal Women's Hospital) University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M","family":"Garland","sequence":"additional","affiliation":[{"name":"Murdoch Childrens Research Institute  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology (Royal Women's Hospital) University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Microbiology and Infectious Diseases Royal Women's Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Neonatal Services Royal Women's Hospital  Melbourne Victoria Australia"},{"name":"Murdoch Childrens Research Institute  Melbourne Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology (Royal Women's Hospital) University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_9_3_1","unstructured":"ChowSSWReport of the Australian and New Zealand Neonatal Network 2010. 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