{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:16:34Z","timestamp":1761059794731},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Preterm infants with respiratory distress syndrome (<jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>) requiring surfactant treatment are often retrieved mechanically ventilated to the receiving hospital. <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IN<\/jats:styled-content>tubate, <jats:styled-content style=\"fixed-case\">SUR<\/jats:styled-content>factant, <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xtubate) technique is not routinely performed by <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ewborn and <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ediatric <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mergency <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ransport <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ervices <jats:styled-content style=\"fixed-case\">NSW<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NETS<\/jats:styled-content>) during retrieval. This study aims to evaluate the likelihood of using <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content> technique during retrieval. We attempted to study the clinical characteristics of preterm infants with <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> who were favourably extubated (<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>) shortly after admission to the receiving hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of preterm infants, gestational age (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) &gt; 28 weeks with <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> requiring retrieval by <jats:styled-content style=\"fixed-case\">NETS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred twenty\u2010three infants, median <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> of 33 weeks (range 29\u201336), median birthweight 2200\u2009g (1000\u20134080) were examined. A percentage of 49.7 received <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>, and 50.3% required <jats:styled-content style=\"fixed-case\">MV<\/jats:styled-content>. Eighteen (16%) infants were <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> (&lt;6\u2009h) at receiving hospital. <jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> on stabilisation (<jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>(st)) by <jats:styled-content style=\"fixed-case\">NETS<\/jats:styled-content> correlated with <jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> on admission to receiving hospital (<jats:italic>r<\/jats:italic> = 0.863). A percentage of 81 of ventilated infants received premedications including morphine. No significant differences were noted for <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>, stabilisation ventilator settings, surfactant dose (mean 155\u2009mg\/kg) and mode of transport between <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> groups. <jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>(st) post\u2010surfactant treatment was significantly lower in <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> compared with non\u2010<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content> group (mean 0.28 vs. 0.41 respectively). The area under the curve from receiver operating characteristic based on <jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>(st) was 0.646 (<jats:italic>P<\/jats:italic> = 0.050), the sensitivity and specificity of <jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>(st) cut\u2010off points (between 0.25 and 0.30) was low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> on stabilisation post\u2010surfactant treatment has a weak predictive value and may not be adequate to be used as sole criteria to extubate to <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> prior to transport. <jats:styled-content style=\"fixed-case\"><jats:roman>FiO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> at stabilisation should be included as an eligibility criteria for a randomised trial of <jats:styled-content style=\"fixed-case\">INSURE<\/jats:styled-content> during retrieval, but other clinical assessments are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12724","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T10:13:48Z","timestamp":1409912028000},"page":"321-327","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is it feasible to identify preterm infants with respiratory distress syndrome for early extubation to continuous positive airway pressure post\u2010surfactant treatment during retrieval?"],"prefix":"10.1111","volume":"51","author":[{"given":"Archana","family":"Priyadarshi","sequence":"first","affiliation":[{"name":"New Born Care Centre Royal Hospital for Women  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Shern","family":"Quek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Luig","sequence":"additional","affiliation":[{"name":"NETS: Newborn and Paediatric Emergency Transport Services  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Lui","sequence":"additional","affiliation":[{"name":"New Born Care Centre Royal Hospital for Women  Sydney New South Wales Australia"},{"name":"Department of Pediatrics The University of New South Wales  Sydney New South Wales 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