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Cerebrospinal fluid analysis showed pleocytosis, and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> grew from enrichment broth. Magnetic resonance imaging revealed an epidural abscess extending from <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>2\u20133 to <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>8\u20139. Staphylococcal infections of the central nervous system are uncommon in neonates. This case demonstrates the importance of performing a lumbar puncture in isolated staphylococcal bacteraemia. 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