{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:29:33Z","timestamp":1773923373573,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the proportion of children with moderate to profound hearing loss who have congenital cytomegalovirus (<jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content>) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective analysis of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> dried blood spot (<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>) polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) in children with moderate to profound hearing impairment referred to tertiary referral centres in <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>ueensland. Participants were under 18 years old with no readily identified cause of hearing impairment, between 2008 and 2011. The primary outcome measure was <jats:styled-content style=\"fixed-case\">DBS CMV PCR<\/jats:styled-content>. Other outcome measures for cases referred to the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildhood <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>earing <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linic (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) at the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ater <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildren's <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital were level of hearing impairment and the neonatal hearing screen result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of <jats:styled-content style=\"fixed-case\">DBS CMV PCR<\/jats:styled-content> testing for 106 children at the <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> for 2008 to 2011 inclusive, nine (8.5%) were positive (five with bilateral hearing impairment, four with unilateral hearing impairment). The prevalence of <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> infection in children with moderate to profound hearing impairment was 8.4%, consistent with the statewide rate of 9.4% for 2008 to mid\u20102011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> is a significant cause of hearing impairment in <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>ueensland children. Investigation for <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> by retrospective <jats:styled-content style=\"fixed-case\">DBS CMV PCR<\/jats:styled-content> should be part of the routine investigation of all babies and young children with hearing impairment. However early diagnosis is preferable and could be achieved by routine early screening of all newborns with hearing impairment for <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> before 3 weeks of age. The healthy hearing screening programme is a routine part of neonatal care. Enhancing the integration of screening for <jats:styled-content style=\"fixed-case\">cCMV<\/jats:styled-content> may reduce the current delays in diagnosis and should be evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12776","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T02:36:21Z","timestamp":1416537381000},"page":"541-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Congenital cytomegalovirus infection is a significant cause of moderate to profound sensorineural hearing loss in <scp>Q<\/scp>ueensland children"],"prefix":"10.1111","volume":"51","author":[{"given":"Christopher J","family":"Toumpas","sequence":"first","affiliation":[{"name":"Department of Paediatrics Mater Children's Hospital  South Brisbane Queensland Australia"},{"name":"Department of Paediatrics Greenslopes Private Hospital  South Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland  South Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lady Cilento Children's Hospital  South Brisbane Queensland Australia"},{"name":"Department of Paediatrics University of Queensland  South Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lady Cilento Children's Hospital  South Brisbane Queensland Australia"},{"name":"Department of Paediatrics University of Queensland  South Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Beswick","sequence":"additional","affiliation":[{"name":"Health Services Support Agency  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare B","family":"Nourse","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lady Cilento Children's Hospital  South Brisbane Queensland Australia"},{"name":"Department of Paediatrics University of Queensland  South Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00023-08"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822d9640"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70328-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.09.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp083"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.08.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2011.tb03144.x"},{"key":"e_1_2_7_9_1","unstructured":"LeCornecG.Queensland Pathology \u2013 Standard Procedure Policy \u2013 CMV TaqMan NAA Blood Spot Method.2009."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5189-5198.2004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.423"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.04.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200301000-00012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181b76b22"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.235"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2012.02711.x"},{"key":"e_1_2_7_17_1","unstructured":"RawlinsonW WilkinsonM HallBet\u2009al.Universal Newborn Hearing Screening Sensorineural Hearing Loss and Contribution of Congenital CMV to the Aetiology. 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