{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:49:04Z","timestamp":1695620944278},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,30]],"date-time":"2014-11-30T00:00:00Z","timestamp":1417305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Worldwide, tuberculin skin tests (<jats:styled-content style=\"fixed-case\">TSTs<\/jats:styled-content>) commonly give false positive results for those who had been given the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>acillus\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>almette\u2010<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uerin vaccine such as is routinely administered in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkey. This study aimed to evaluate the patients referred to us who had positive <jats:styled-content style=\"fixed-case\">TSTs<\/jats:styled-content> despite lack of tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) disease contacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eptember 2011 and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eptember 2012, 183 patients were prospectively evaluated for differential diagnosis of <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> positivity despite lack of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> disease contact. They were then followed up by us to determine an accurate diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among our patients' most common symptoms indicating a need for <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> were chronic cough, productive cough or sputum expectoration, and recurrent or persistent wheezing. Chest x\u2010rays were taken of all patients, and the findings were noted. Interferon gamma release assays were performed on 75% of the patients, of which 96% were negative for <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>. The most common final diagnoses were asthma (44%), allergic rhinitis (13%), bronchopneumonia (11%) and reactive lymphadenitis (6.5%). Further evaluations for <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> were required of 36 patients, and <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> disease was established in 12 of them (6.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients who had had no known <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> contact, the most common symptom indicating need for <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> was chronic cough; the most common diagnoses were asthma and allergic rhinitis. Cavitary lesions, haemoptysis, persistent infiltration, pleural effusion and thoracic lymphadenopathy despite antibiotherapy should alert physicians to the possibility of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12779","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T01:58:10Z","timestamp":1417399090000},"page":"632-638","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tuberculin skin test positivity without tuberculosis contact: A major challenge in childhood"],"prefix":"10.1111","volume":"51","author":[{"given":"Ahmet Hakan","family":"Gedik","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology Bezmialem Vakif University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Cakir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology Bezmialem Vakif University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tugrul","family":"Donmez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Bezmialem Vakif University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engin","family":"Ari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Bezmialem Vakif University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orhan Kaya","family":"Koksalan","sequence":"additional","affiliation":[{"name":"Molecular Tuberculosis Epidemiology Laboratory Institute for Medical Experimental Research (DETAE) Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,30]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Global Tuberculosis Report","author":"WHO","year":"2012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199512000-00006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0498"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.070797"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2004.03.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_9_8_1","unstructured":"Global Initiative for Asthma.Global strategy for asthma management and prevention. 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