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In 1965, survival was almost zero; now 5\u2010year survival rates exceed 80% in high\u2010income countries. The lessons learned in the care of patients with the most common malignancy in childhood \u2013 acute lymphoblastic leukaemia \u2013 have been used in all other cancers of childhood and more recently in the management of adults. These lessons can be broadly applied in medical practice, because elements of laboratory science in all branches of pathology, as well as a deep understanding of biochemistry, physiology, pharmacology, genetics and molecular science, run through this story. Far from being a sad area of practice, paediatric haematology and oncology remains the champion of embedded clinical and translational research, diagnosis from bench to bedside and lifelong multidisciplinary management of the child and their family.<\/jats:p>","DOI":"10.1111\/jpc.12803","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T09:34:13Z","timestamp":1421228053000},"page":"78-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lessons from 50 years of curing childhood leukaemia"],"prefix":"10.1111","volume":"51","author":[{"given":"Catherine Helen","family":"Cole","sequence":"first","affiliation":[{"name":"School of Paediatrics and Child Health University of Western Australia  Perth Western Australia Australia"},{"name":"Department of Paediatric and Adolescent Haematology and Oncology Princess Margaret Hospital  Perth Western Australia Australia"},{"name":"Heamatology Laboratory PathWest  Perth Western Australia Australia"},{"name":"Telethon Kids' Institute  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194806032382301"},{"key":"e_1_2_10_3_1","volume-title":"The Emperor of all Maladies \u2013 A Biography of Cancer","author":"Mukherjee S","year":"2010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V18.4.431.431"},{"key":"e_1_2_10_5_1","first-page":"1605","article-title":"The management of acute leukemia","volume":"96","author":"Freireich EJ","year":"1967","journal-title":"Can. 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