{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:31:58Z","timestamp":1763641918026},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["572742"],"award-info":[{"award-number":["572742"]}]},{"name":"NHMRC Principle Research Fellowship","award":["634341"],"award-info":[{"award-number":["634341"]}]},{"name":"NHMRC Career Development Fellowship","award":["632955"],"award-info":[{"award-number":["632955"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>A recent international study reported a higher prevalence of oesophageal atresia with or without tracheo\u2010oesophageal fistula (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\u00b1<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>) in Western <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia (<jats:styled-content style=\"fixed-case\">WA<\/jats:styled-content>). The aim of this study was to examine the prevalence and trends of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">WA<\/jats:styled-content>, determine the proportion of cases with associated anomalies and explore the impact of time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised all infants born in <jats:styled-content style=\"fixed-case\">WA<\/jats:styled-content>, 1980\u20132009, and registered with <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> on the <jats:styled-content style=\"fixed-case\">WA<\/jats:styled-content> Register of Developmental Anomalies (<jats:styled-content style=\"fixed-case\">WARDA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\u00b1<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> alone affect, on average, one in every 2927 births in <jats:styled-content style=\"fixed-case\">WA<\/jats:styled-content>, with a total prevalence of 3.00 and 0.42 per 10\u2009000 births, respectively. The prevalence of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\u00b1<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> increased by 2.0% per annum, with only cases with associated anomalies (64% of cases) demonstrating an increase. <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> rates were stable. Among <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\u00b1<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> infants, the proportion of live births, stillbirths and elective terminations of pregnancy for fetal anomaly (<jats:styled-content style=\"fixed-case\">TOPFA<\/jats:styled-content>) was 79%, 6% and 15%, respectively, whereas the majority (94%) of <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> only cases were live births. In 2000\u20132009, there was 30% fall in <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\u00b1<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> live births with 61 (58%) cases diagnosed in first week of life, 10 (9%) prenatally and 34 (32%) at post\u2010mortem only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A higher prevalence of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\u00b1<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">WA<\/jats:styled-content> was observed with increase over time attributable to increase with associated anomalies. Consistent reporting, availability of prenatal diagnosis and ascertainment of cases following <jats:styled-content style=\"fixed-case\">TOPFA<\/jats:styled-content> or post\u2010mortem examinations can significantly affect prevalence of <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12909","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T06:14:07Z","timestamp":1431670447000},"page":"1023-1029","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Oesophageal atresia and tracheo\u2010oesophageal fistula in <scp>W<\/scp>estern <scp>A<\/scp>ustralia: Prevalence and trends"],"prefix":"10.1111","volume":"51","author":[{"given":"Emanuele","family":"Leoncini","sequence":"first","affiliation":[{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Bower","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"},{"name":"Western Australian Register of Developmental Anomalies King Edward Memorial Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Nassar","sequence":"additional","affiliation":[{"name":"Clinical and Population Perinatal Health Research Kolling Institute of Medical Research University of Sydney Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.6.743"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.038158"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-24"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420520408"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370110205"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20592"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2006.12.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23067"},{"key":"e_1_2_8_10_1","unstructured":"BowerC RudyE CallaghanAReport of the Birth Defects Registry of Western Australia 1980\u20132010. 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