{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:08:31Z","timestamp":1775012911169,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Aim<\/jats:title>Chronic abdominal pain (CAP<\/jats:styled-content>) in childhood is common and in the majority functional. While CAP<\/jats:styled-content> is one of the complaints of coeliac disease (CD<\/jats:styled-content>), whether CAP<\/jats:styled-content> as a sole complaint is indicative of CD<\/jats:styled-content> is unclear. Our aim was to evaluate the relationship between CAP<\/jats:styled-content> and CD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study was conducted on 1047 children (61.1% female, mean age 9.6 \u00b1 4.1 years) with CAP<\/jats:styled-content>. Patients were evaluated according to the R<\/jats:styled-content>ome III<\/jats:styled-content> criteria. Patients with alarm symptoms and conditions known to be associated with CD<\/jats:styled-content> were excluded. Patients were screened for CD<\/jats:styled-content> using a rapid tissue transglutaminase (tTG<\/jats:styled-content>) test; positive cases were tested by tTG ELISA<\/jats:styled-content>, and duodenal biopsies were obtained if tTG<\/jats:styled-content> was above the normal limit.<\/jats:p><\/jats:sec>Results<\/jats:title>Functional dyspepsia (FD<\/jats:styled-content>), irritable bowel syndrome (IBS<\/jats:styled-content>) and functional abdominal pain (FAP<\/jats:styled-content>) were diagnosed in 384 (36.7%), 274 (26.2%) and 389 (37.2%) patients, respectively. In 13 patients, the tTG rapid test was positive; 10 were also positive for tTG<\/jats:styled-content> by ELISA<\/jats:styled-content> and histopathological evaluations diagnosed CD<\/jats:styled-content> in all 10 patients. The overall prevalence of CD<\/jats:styled-content> was 0.95% (2.2%, 0.5% and 0.5% in patients with IBS<\/jats:styled-content>, FD<\/jats:styled-content> and FAP<\/jats:styled-content>, respectively). The prevalence of CD<\/jats:styled-content> in patients with IBS<\/jats:styled-content> was higher than expected but with borderline statistical significance (P<\/jats:italic> = 0.053).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CD<\/jats:styled-content> is found as common in children with FD<\/jats:styled-content> and FAP<\/jats:styled-content> as in the general population. CD<\/jats:styled-content> was more commonly diagnosed in IBS<\/jats:styled-content> patients with borderline statistical significance. We suggest that particular attention be paid to children with IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12929","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T02:09:30Z","timestamp":1433383770000},"page":"1066-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Yield of coeliac screening in abdominal pain\u2010associated functional gastrointestinal system disorders"],"prefix":"10.1111","volume":"51","author":[{"given":"Aydan","family":"Kansu","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology School of Medicine Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarife","family":"Kulo\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology School of Medicine Ankara University Ankara 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