{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:17:06Z","timestamp":1784715426553,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"crossref","award":["FF-2013-413"],"award-info":[{"award-number":["FF-2013-413"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Aims<\/jats:title>The aim of this study was to determine the occurrence of renal cortical scarring and chronic kidney disease (CKD<\/jats:styled-content>) in children with neurogenic bladder secondary to spina bifida (SB<\/jats:styled-content>) managed at the U<\/jats:styled-content>niversiti K<\/jats:styled-content>ebangsaan M<\/jats:styled-content>alaysia M<\/jats:styled-content>edical C<\/jats:styled-content>entre. The secondary objective was to identify the clinical factors associated with these adverse outcomes.<\/jats:p><\/jats:sec>Methods<\/jats:title>The medical records of 56 children managed from 1997 were available. Socio\u2010demographic and clinical data for SB<\/jats:styled-content> children managed for a minimum of 2 years (n<\/jats:italic> = 45) were reviewed. This included age at referral, gender, ethnicity, duration of care, type of SB<\/jats:styled-content> lesion, presence of vesico\u2010ureteric reflux (VUR<\/jats:styled-content>), symptomatic urinary tract infections, bladder trabeculation, catheterisations and renal function.<\/jats:p><\/jats:sec>Results<\/jats:title>Forty\u2010nine per cent of SB<\/jats:styled-content> lesions were open myelomeningocoele, 40% were closed lesions and 11% were occult. Majority (96%) were at lumbar L3 or below. Twenty\u2010nine children (64.5%) were referred before 6 months of age (mean15.8 months; range newborn to 125 months). Thirty\u2010five (77.8%) had neurogenic bladder and 31(69%) had neurogenic bowel. Sixteen developed renal scarring and six, CKD<\/jats:styled-content>. Late referral (\u22656 months of age), small kidneys at referral, dilating VUR<\/jats:styled-content> and bladder trabeculation were significant independent factors associated with scarring. On multivariate analysis, late referral (odds ratio (OR<\/jats:styled-content>) 17.4; 95% confidence interval (CI<\/jats:styled-content>) 1.26\u2013238.7) and dilating VUR<\/jats:styled-content> (OR<\/jats:styled-content> 137.0; CI<\/jats:styled-content> 6.4\u20132921.1) remained significant.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Prevention of renal scarring and CKD<\/jats:styled-content> remains a challenge in M<\/jats:styled-content>alaysia even with multidisciplinary proactive care of SB<\/jats:styled-content> children. Early referrals and more stringent management strategies for dilating VUR<\/jats:styled-content> are still required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.12938","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T02:10:14Z","timestamp":1433383814000},"page":"1175-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Renal scarring and chronic kidney disease in children with spina bifida in a multidisciplinary M<\/scp>alaysian centre"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-5691","authenticated-orcid":false,"given":"Yoganathan","family":"Kanaheswari","sequence":"first","affiliation":[{"name":"Department of Paediatrics Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Manaf","family":"Mohd Rizal","sequence":"additional","affiliation":[{"name":"Department of Community Health Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2014.03.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05374.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0780-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0691-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.056"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-010-9894-5"},{"key":"e_1_2_9_8_1","first-page":"12","article-title":"Malaysian children with spina bifida: relationship between functional outcome and level of lesion","volume":"43","author":"Ong LC","year":"2002","journal-title":"Singapore Med. J."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/650482"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"S1","article-title":"KDOQI Clinical Practice Guidelines for Chronic Kidney Disease: evaluation, classification and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am. J. Kidney. Dis."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36251-4"},{"key":"e_1_2_9_12_1","first-page":"365","volume-title":"Pediatric Urology Practice","author":"Kraus SR","year":"1999"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64112-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106326"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2007.11753966"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54449-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0764-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048399"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpc.12938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.12938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:42:14Z","timestamp":1695480134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.12938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,3]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jpc.12938"],"URL":"https:\/\/doi.org\/10.1111\/jpc.12938","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,3]]},"assertion":[{"value":"2015-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}