{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:05:07Z","timestamp":1773281107856,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A previous randomised controlled trial (RCT) in babies born &lt;\u200930 weeks gestation found the so\u2010called CICADA method (ceasing continuous positive airways pressure (CPAP) with a view to remain off rather than slow weaning) significantly reduced CPAP time. Post\u2010RCT we introduced the CICADA method and evaluated whether the improved outcomes of the CICADA method during the RCT were replicated in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study is to compare cardio\u2010respiratory outcomes in PBs\u2009&lt;\u200930\u2009weeks GA over three epochs: (i) pre RCT, (ii) during RCT and (iii)  post RCT implementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study used prospective data to compare baseline characteristics and cardio\u2010respiratory outcomes over the three epochs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 270\/393(69%) PBs &lt;\u200930\u2009weeks GA who fulfilled the inclusion criteria over the three epochs. No significant differences were found in GA or birthweight between the three epochs (27.9\u2009\u00b1\u20091.3, 27.7\u2009\u00b1\u20091.4, 28.0\u2009\u00b1\u20091.3 (weeks\u2009\u00b1\u20091 standard deviation); and 1100\u2009\u00b1\u2009252, 1086\u2009\u00b1\u2009251, 1094\u2009\u00b1\u2009320 (grams\u2009\u00b1\u20091 standard deviation)). There were significant decreases in CPAP days and corrected GA to cease CPAP post implementation (20.5\u2009\u00b1\u20092.1, 21.1\u2009\u00b1\u20092.1, 16.5\u2009\u00b1\u20091.8 (days\u2009\u00b1\u2009SE); <jats:italic>P<\/jats:italic>\u2009=\u20090.006 and 33.3\u2009\u00b1\u20090.4, 33.5\u2009\u00b1\u20090.4, 32.6\u2009\u00b1\u20090.4 (weeks\u2009\u00b1\u2009SE); <jats:italic>P<\/jats:italic>\u2009=\u20090.01). Compared with the pre RCT epoch, there were significant reductions in patent ductus arteriosus (36\/78 (46%), 33\/87 (37%), 18\/103 (17%); <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and chronic lung disease (40\/78 (51%), 19\/87 (21%), 30\/103 (29%); <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CPAP time, corrected GA to cease CPAP, patent ductus arteriosus and chronic lung disease significantly reduced following the introduction of the CICADA method. Early cessation of CPAP expedites the transition from neonatal intensive care to special care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.13087","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T00:41:46Z","timestamp":1461976906000},"page":"321-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CeasIng Cpap At standarD criteriA (CICADA): Implementation improves neonatal outcomes"],"prefix":"10.1111","volume":"52","author":[{"given":"Rachael C","family":"Heath Jeffery","sequence":"first","affiliation":[{"name":"Australian National University Medical School  Canberra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Broom","sequence":"additional","affiliation":[{"name":"Department of Neonatology Centenary Hospital  Canberra"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Shadbolt","sequence":"additional","affiliation":[{"name":"Australian National University Medical School  Canberra"},{"name":"Centre for Advances in Epidemiology and IT Canberra Hospital Garran  Canberra Australian Capital Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Todd","sequence":"additional","affiliation":[{"name":"Australian National University Medical School  Canberra"},{"name":"Department of Neonatology Centenary Hospital  Canberra"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197106172842401"},{"key":"e_1_2_9_3_1","first-page":"CD002271","article-title":"Continuous distending pressure for respiratory distress syndrome in preterm infants [Review]","author":"Ho JJ","year":"2002","journal-title":"Cochrane Database Syst. 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